SGDI: SYSTEM FOR GENOMIC DATA INTEGRATION

机译：SGDI：基因数据集成系统

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This paper describes a framework for collecting, annotating, and archiving high-throughput assays from multiple experiments conducted on one or more series of samples. Specific applications include support for large-scale surveys of related transcriptional profiling studies, for investigations of the genetics of gene expression and for joint analysis of copy number variation and mRNA abundance. Our approach consists of data capture and modeling processes rooted in R/Bioconductor, sample annotation and sequence constituent ontology management based in R, secure data archiving in PostgreSQL, and browser-based workspace creation and management rooted in Zope. This effort has generated a completely transparent, extensible, and customizable interface to large archives of high-throughput assays.

机译：本文描述了一个框架，该框架用于从对一个或多个系列样本进行的多个实验中收集，注释和存档高通量分析。具体应用包括支持相关转录谱研究的大规模调查，基因表达遗传学的调查以及拷贝数变异和mRNA丰度的联合分析。我们的方法包括基于R / Bioconductor的数据捕获和建模过程，基于R的样本注释和序列组成本体管理，基于PostgreSQL的安全数据归档以及基于Zope的基于浏览器的工作区创建和管理。这项工作已经为高通量检测的大型档案生成了一个完全透明，可扩展和可定制的界面。

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来源
《Pacific Symposium on Biocomputing; 20080104-08; Kohala Coast,HI(US)》|2008年|P.141152|共2页
会议地点 Kohala CoastHI(US)
作者
V. J. CAREY; J. GENTRY; D. SARKAR; R. GENTLEMAN; S. RAMASWAMY;
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作者单位

Channing Laboratory, Brigharn and Women's Hospital Harvard Medical School 181 Longwood Avenue, Boston, MA 02115, USA;

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原文格式 PDF
正文语种 eng
中图分类计算机的应用;生物工程学（生物技术）;
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SGDI: SYSTEM FOR GENOMIC DATA INTEGRATION

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