EXPLORING PROTEIN FOLDING TRAJECTORIES USING GEOMETRIC SPANNERS

机译：使用几何标尺探索蛋白质折叠轨迹

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We describe the 3-D structure of a protein using geometric spanners — geometric graphs with a sparse set of edges where paths approximate the n~2 inter-atom distances. The edges in the spanner pick out important proximities in the structure, labeling a small number of atom pairs or backbone region pairs as being of primary interest. Such compact multiresolution views of proximities in the protein can be quite valuable, allowing, for example, easy visualization of the conformation over the entire folding trajectory of a protein and segmentation of the trajectory. These visualizations allow one to easily detect formation of secondary and tertiary structures as the protein folds.

机译：我们使用几何扳手（一种具有稀疏边缘集的几何图来描述蛋白质的3-D结构），其中路径近似于n〜2个原子间的距离。扳手的边缘挑出了结构中的重要位置，将少数原子对或骨架区域对标记为主要关注对象。这种接近蛋白质的紧凑的多分辨率视图可能非常有价值，例如，可以轻松查看整个蛋白质折叠轨迹上的构象和轨迹的分段。这些可视化功能使人们可以轻松地检测蛋白质折叠时二级和三级结构的形成。

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来源
《Pacific Symposium on Biocomputing(PSB); 20050104-08; Hawaii,HI(US)》|2005年|P.40-51|共12页
会议地点 HawaiiHI(US)
作者
D. RUSSEL; L. GUIBAS;
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Computer Science Department 353 Serra Mall Stanford, CA 94305, USA;

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原文格式 PDF
正文语种 eng
中图分类计算机的应用;生物工程学（生物技术）;
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专利

1. Relative measure of geometrical entanglement to study folding-unfolding transitions. Application to analysis of molecular dynamics trajectories of proteins in vacuo [J] . Arteca GA., Tapia O. International Journal of Quantum Chemistry . 2000,第4a5期

机译：几何纠缠的相对度量，用于研究折叠-展开过渡。在真空中蛋白质分子动力学轨迹分析中的应用
2. Exploring the folding pathways of annexin I, a multidomain protein. II. Hierarchy in domain folding propensities may govern the folding process [J] . Cordier-Ochsenbein F., Russo-Marie F., Neumann JM., Journal of Molecular Biology . 1998,第5期

机译：探索膜联蛋白I（一种多域蛋白）的折叠途径。二。域折叠倾向中的层次结构可以控制折叠过程
3. The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanisms. [J] . Connell KB, Miller EJ, Marqusee S Journal of Molecular Biology . 2009,第2期

机译：RNase H的折叠轨迹主要受其拓扑结构而不是局部稳定性的影响：一项蛋白质工程研究，研究了通过二态和三态机制折叠的变异体。
4. EXPLORING PROTEIN FOLDING TRAJECTORIES USING GEOMETRIC SPANNERS [C] . D. RUSSEL, L. GUIBAS Pacific Symposium on Biocomputing . 2005

机译：使用几何扳手探索蛋白质折叠轨迹
5. The geometrical analysis of the structure of proteins with implications for protein folding. [D] . Drennan, Diana Jean. 2001

机译：蛋白质结构的几何分析及其对蛋白质折叠的影响。
6. The folding trajectory of RNase H is dominated by its topology and not local stability: a protein engineering study of variants that fold via two-state and three-state mechanism [O] . Katelyn B. Connell, Erik J. Miller, Susan Marqusee -1

机译：RNa酶H的折叠轨迹是由它的拓扑结构为主而不是局部稳定性：经由两态和三态机制折变体的蛋白质工程研究
7. The Folding Trajectory of RNase H Is Dominated by Its Topology and Not Local Stability: A Protein Engineering Study of Variants that Fold via Two-State and Three-State Mechanisms [O] . Katelyn B. Connell, Erik J. Miller, Susan Marqusee 2009

机译：RNase H的折叠轨迹由其拓扑结构而不是局部稳定性：通过两个状态和三状态机制折叠的变体的蛋白质工程研究

EXPLORING PROTEIN FOLDING TRAJECTORIES USING GEOMETRIC SPANNERS

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