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首页> 外文会议>Photodynamic Therapy of Cancer >Photodynamic tumor therapy and on-line fluorescence spectroscopy after aminolevulinic acid administration using 633-nm light as therapeutic and fluorescence excitation radiation
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Photodynamic tumor therapy and on-line fluorescence spectroscopy after aminolevulinic acid administration using 633-nm light as therapeutic and fluorescence excitation radiation

机译：氨基乙酰丙酸给药后的光动力学肿瘤治疗和在线荧光光谱，使用633 nm光作为治疗和荧光激发辐射

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摘要

Abstract: PDT and on-line fluorescence spectroscopy were carried out on human tumors after ALA- administration using 633 nm-light of a dye laser as therapeutic radiation and as fluorescence excitation radiation. This has the following advantages: (1) use of one laser for PDT and fluorescence diagnosis only, (2) the possibility of on-line fluorescence measurements, and (3) excitation of protoporphyrin molecules in deep tissue layers. Monte Carlo calculations were carried out to determine the excitation and fluorescence photon distribution in the case of red and violet excitation radiation. The results show the possibility of depth-resolved measurements on the fluorophore distribution by variation of the excitation wavelength. The influence of remitted excitation light and of the spontaneous radiation from the laser as well as the possible excitation of food-based degradation products of chlorophyll has to be considered in high-sensitive fluorescence measurements. !12
机译：摘要：在ALA给药后，以633 nm的染料激光作为治疗辐射和荧光激发辐射，对人肿瘤进行了PDT和在线荧光光谱。这具有以下优点：（1）仅将一台激光用于PDT和荧光诊断；（2）在线荧光测量的可能性；以及（3）在深层组织层中激发原卟啉分子。进行了蒙特卡洛计算以确定红色和紫色激发辐射情况下的激发和荧光光子分布。结果表明，通过改变激发波长，可以对荧光团分布进行深度解析测量。在高灵敏度的荧光测量中，必须考虑到所激发的激发光和激光的自发辐射的影响，以及基于食物的叶绿素降解产物的可能激发。 ！12

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