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Light delivery schemes for uterine photodynamic therapy

机译：子宫光动力疗法的光传输方案

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Abstract: The use of photodynamic therapy in the removal of the endometrial layer of the uterus provides the possibility of a rapid and effective treatment of menorrhagia avoiding the difficulties and complications of conventional methods. A treatment is proposed in which topical application of 5-aminolaevulinic acid to the inner surface of the uterus is followed by illumination at 630 nm. The surface layer would in this way be rendered necrotic to slough off over subsequent days. The removal of the entire endometrium must be achieved in order to prevent the return of the original condition, which demands that a therapeutic dose of both light and photosensitizer must be achieved throughout the depth of the tissue. This work presents a method of light delivery suitable for intra-uterine PDT along with in vitro optical phantom and ex vivo tissue measurements that aid in the characterization of the light field prior to treatment. These measurements allow the prediction of a treatment time suitable for the delivery of an effective light dose. !11
机译：摘要：光动力疗法在子宫内膜层切除术中的应用为快速有效地治疗月经过多提供了可能，避免了传统方法的困难和并发症。提出了一种治疗方法，其中在子宫内表面局部应用5-氨基乙酰戊酸，然后在630 nm处照射。通过这种方式，表面层将在随后的几天内坏死掉落。为了防止原始状况的恢复，必须实现整个子宫内膜的去除，这要求在整个组织的整个深度都必须达到治疗剂量的光敏剂和光敏剂。这项工作提出了一种适合子宫内PDT的光传输方法，以及体外光学体模和离体组织的测量方法，有助于在治疗前表征光场。这些测量值允许预测适合于递送有效光剂量的治疗时间。 ！11

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