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Effect of sulfonation on the photosensitizing efficiency of aluminum phthalocyanine and meso-tetraphenylporphine in photodynamic therapy of cancer

机译:磺化对铝酞菁和内消旋四苯基卟啉在光动力疗法中光敏作用的影响

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Abstract: The effect of sulfonations on the PDT efficiency of aluminum phthalocyanines and meso- tetraphenylporphines was studied in the CaD2 mouse mammary carcinoma. The PDT efficiencies were found to decrease in the following order: AlPCS$-2$/ $GRT AlPCS$-4$/ $GRT Photofrin $GRT TPPS$-2a$/ $GRT AlPCS$-1$/ $GRT TPPS$-4$/ $GRT TPPS$-2o$/ $GRT TPPS$-1$/. Apparently, the degree of sulfonations of both families of dyes strongly affects the photobiological properties. It was found to be of great importance whether the sulfonate groups were located adjacently or opposite positions on the molecules. !53
机译:摘要:研究了磺化作用对CaD2小鼠乳腺癌中铝酞菁和间四苯基卟啉的PDT效率的影响。发现PDT效率按以下顺序降低:AlPCS $ -2 $ / $ GRT AlPCS $ -4 $ / $ GRT Photofrin $ GRT TPPS $ -2a $ / $ GRT AlPCS $ -1 $ / $ GRT TPPS $- 4 $ / $ GRT TPPS $ -2o $ / $ GRT TPPS $ -1 $ /。显然,两个染料家族的磺化程度都强烈影响光生物学特性。发现非常重要的是磺酸盐基团是位于分子上的相邻位置还是相反位置。 !53

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