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Distribution of photosensitizers between tumor cells and tumor infiltrating host cells

机译：光敏剂在肿瘤细胞和肿瘤浸润宿主细胞之间的分布

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Abstract: Photofrin levels in different cellular populations constituting a murine FsaR fibrosarcoma were measured by flow cytometry. Both myeloid and lymphoid populations associated with the tumor were found to accumulate more photosensitizer on a per cell basis, on average, than the malignant cells. Macrophages, identified by the F4/80 antigen, exceeded other myeloid cells in Photofrin accumulation. It is shown that one of the factors involved is the variability in the photosensitizer content in cells located at different distances from the nearest blood vessel. This was investigated by a flow cytometry technique with the fluorescent stain Hoechst 33342, used to distinguish cells depending on their proximity to the tumor vasculature. !14

机译：摘要：通过流式细胞仪测量了组成鼠FsaR纤维肉瘤的不同细胞群中的光合蛋白水平。发现与肿瘤相关的髓样和淋巴样群体在每个细胞的基础上平均比恶性细胞积累更多的光敏剂。由F4 / 80抗原鉴定的巨噬细胞超过了Photofrin积累中的其他髓样细胞。结果表明，所涉及的因素之一是距最近血管不同距离的细胞中光敏剂含量的变化。通过流式细胞术技术对荧光染色的Hoechst 33342进行了研究，该染色用于根据细胞与肿瘤脉管系统的接近程度来区分细胞。！14

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来源
《Photodynamic Therapy of Cancer》|1993年|p.389-396|共8页
会议地点 Budapest(HU)
作者
Mladen Korbelik; British Columbia Cancer Research Ctr.; Vancouver; British Columbia; Canada; Gorazd Krosl; British Columbia Cancer Research Ctr.; Vancouver; British Columbia; Canada.;
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正文语种 eng
中图分类无线电电子学、电信技术;
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机译：二次离子质谱法（SIMS）在脑肿瘤和浸润性肿瘤细胞中以单细胞分辨率对镁分布进行定量成像
2. Tumor-infiltrating CD5(+) regulatory B1 cells suppress melanoma tumor immunity via inhibiting cytokine production of tumor-infiltrating CD8(+) T cells [J] . Kobayashi T., Matsushita T., Hamaguchi Y., The Journal of investigative dermatology. . 2018,第5a19期

机译：肿瘤浸润CD5（+）调节B1细胞通过抑制肿瘤浸润的CD8（+）T细胞的细胞因子产生抑制黑素瘤肿瘤抗扰度
3. Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer [J] . Takanori Maruyama Koji Kono, Takanori Maruyama Koji Kono Cancer Science . 2010,第9期

机译：胃癌患者肿瘤浸润淋巴细胞，引流淋巴结和外周血淋巴细胞中Th17细胞和FoxP3（+）调节性T细胞的分布
4. Distribution of photosensitizers between tumor cells and tumor infiltrating host cells [C] . Mladen Korbelik, Gorazd Krosl Conference on photodynamic therapy of cancer . 1994

机译：肿瘤细胞与肿瘤浸润宿主细胞之间的光敏剂分布
5. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor in solid tumors. [D] . Priceman, Saul Jonathan. 2009

机译：通过抑制实体瘤中的CSF-1受体靶向不同的浸润肿瘤的骨髓细胞。
6. Quantitative imaging of magnesium distribution at single-cellresolution in brain tumors and infiltrating tumor cells with secondary ion massspectrometry (SIMS) [O] . Subhash Chandra, Dylan J. Parker, Rolf F. Barth, -1

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7. Functional Analysis of Mononuclear Cells Infiltrating into Tumors: Establishment of a New System to Obtain Functionally Active Tumor-infiltrating Cells [O] . Noriharu Shijubo, Toshimitsu Uede, Naohiro Nomura, 1990

机译：渗透到肿瘤中单核细胞的功能分析：建立新系统，以获得功能活性肿瘤渗透细胞

Distribution of photosensitizers between tumor cells and tumor infiltrating host cells

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