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首页> 外文会议>Photon Migration and Imaging in Random Media and Tissues >Time-resolved spectroscopy and the determination of photon scattering pathlength and brain vascular hemoglobin saturation in a population of normal volunteers
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Time-resolved spectroscopy and the determination of photon scattering pathlength and brain vascular hemoglobin saturation in a population of normal volunteers

机译：正常志愿者人群中的时间分辨光谱和光子散射光程和脑血管血红蛋白饱和度的测定

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Abstract: Determining the relationship between light absorption and chromophore concentration in brain is complicated by photon scattering, which makes it difficult to determine pathlength. In the current study we apply newly developed phase modulation (PMS) and time-resolved (TRS) spectrometers to determine tissue scattering, pathlength and brain vascular hemoglobin saturation (BVH). PMS measurements were made from both frontal cortices of 36 adults using light guides separated by 4 cm and tightly placed against the forehead. TRS measurements were done with a 5 cm probe separation. For the PMS measurements, changes in phase shift were detected at 754 and 816 nm wavelengths. For TRS, the wavelength was 670 nm in all subjects, and some subjects had additional measurements made at a wavelength of 820 nm. Scattering and the extrapolated pathlength in the absence of hemoglobin were determined from the TRS data. This information was combined with the PMS data to determine BVH. The coefficient variation for the calculated saturation was only 0.04. This suggests both scattering and pathlength have significant intersubject variability and need to be explicitly determined for appropriate calculation of hemoglobin saturation. !6
机译：摘要：确定光吸收与脑中发色团浓度之间的关系由于光子散射而变得复杂，这使得难以确定光程长度。在当前的研究中，我们应用新开发的相位调制（PMS）和时间分辨（TRS）光谱仪来确定组织散射，光程和脑血管血红蛋白饱和度（BVH）。 PMS测量是由36位成年人的两个额叶皮质进行的，使用相距4 cm并紧紧贴在前额上的光导。 TRS测量使用5 cm的探针间隔进行。对于PMS测量，在754和816 nm波长处检测到相移的变化。对于TRS，所有受试者的波长均为670 nm，有些受试者在820 nm波长下进行了其他测量。从TRS数据确定在不存在血红蛋白的情况下的散射和外推路径长度。该信息与PMS数据结合确定BVH。计算出的饱和度的系数变化仅为0.04。这表明散射和光程长度都具有明显的受试者间变异性，需要明确确定血红蛋白饱和度的适当计算量。 ！6

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