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首页> 外文会议>Photonic Therapeutics and Diagnostics II; Progress in Biomedical Optics and Imaging; vol.7, no.1 >Simultaneous Spectrophotometric and Mechanical Property Characterization of Skin
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Simultaneous Spectrophotometric and Mechanical Property Characterization of Skin

机译：皮肤同时分光光度法和力学性能表征

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摘要

Both reflectance spectroscopy and the determination Young's Modulus of skin have shown promise for identifying skin pathology. At present, these determinations are carried out using separate methodologies. This study demonstrates a new technology combining digital UV/VIS reflectance spectroscopy and vacuum aspiration for simultaneously determining the reflectance spectrum and mechanical properties of human skin tissue. A small hand held prototype device incorporating fiber-optic light guides into a vacuum channel was calibrated using various elastic materials subjected to increments of stress by vacuum from 0 to 25 in Hg. The intensity of a UV/VIS light beam reflected from the material at each vacuum increment was compared to the resulting material strain. The reflected beam was also spectrophotometrically analyzed. Skin types were similarly evaluated comparing normal and scar tissue and skin of various ages and coloration. An exponential relationship between reflected beam intensity and the amount of strain resulting from vacuum increments was observed. Young's Modulus (calculated from Aoki et. al equation) and spectra from normal skin and scar tissue were in agreement with previously published observations. Age related decreases in skin elasticity were also demonstrated. In the reflectance spectra, oxy and deoxy-hemoglobin absorbance bands were detected, becoming significantly enhanced at increased levels of vacuum. Melanin absorbance was also easily detected and appeared to correlate with skin coloration. Since superficial skin pathologies have characteristic spectroscopic and mechanical properties, this technique may provide a promising new approach for rapid, non-invasive method for the evaluation of skin lesions.
机译：反射光谱法和测定皮肤的杨氏模量均显示出鉴定皮肤病理学的希望。目前，这些确定是使用单独的方法进行的。这项研究演示了一种结合了数字UV / VIS反射光谱学和真空抽吸技术的新技术，可以同时测定人体皮肤组织的反射光谱和机械性能。使用各种弹性材料校准了一个将光纤光导引入真空通道的小型手持原型设备，该材料经受了从0到25 in Hg的真空压力增加。将在每个真空增量处从材料反射的UV / VIS光束的强度与所得材料应变进行比较。还用分光光度法分析了反射光束。类似地评估了皮肤类型，比较了正常和疤痕组织以及不同年龄和肤色的皮肤。观察到反射光束强度与真空增量导致的应变量之间呈指数关系。杨氏模量（根据Aoki等人的公式计算）以及正常皮肤和疤痕组织的光谱与先前发表的观察结果一致。还证实了年龄相关的皮肤弹性下降。在反射光谱中，检测到了氧和脱氧血红蛋白的吸收带，并在真空度增加时显着增强。黑色素的吸收也很容易被检测到，并且似乎与皮肤的颜色有关。由于浅层皮肤病理学具有特征性的光谱学和机械性能，因此该技术可为快速，无创的​​皮肤病变评估方法提供有希望的新方法。

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