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首页> 外文会议>Photonic Therapeutics and Diagnostics III; Progress in Biomedical Optics and Imaging; vol.8 no.1; Proceedings of SPIE-The International Society for Optical Engineering; vol.6424 >Vascular-Targeted Photodynamic of Prostate Cancer Phase with Tookad for Recurrent Prostate Cancer Following Radiation Therapy: Initial Clinical Studies
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Vascular-Targeted Photodynamic of Prostate Cancer Phase with Tookad for Recurrent Prostate Cancer Following Radiation Therapy: Initial Clinical Studies

机译：Tookad用于前列腺癌放疗后复发性前列腺癌的血管靶向光动力学研究：初步临床研究

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摘要

We report on the first clinical application of vascular-targeted photodynamic therapy using a bacteriopheophorbide derivative, Tookad, in patients with localized prostate cancer following external beam radiation therapy. Patients received either escalating intravenous drug doses at a fixed light dose or escalated light doses at the highest photosensitizer dose. Two cylindrically diffusing fibers were placed transperineally in the prostate, along with light monitoring fibers in the prostate, urethra and rectum. Treatment response was assessed with 7-day gadolinium-enhanced Tl-weighted MRI and 6-month biopsy. Lesion formation was strongly drug and light dose-dependent, with an apparent threshold response. Early biochemical and MRI responses support the clinical potential of TOOKAD-PDT to treat locally-recurrent prostate cancer.
机译：我们报道了在体外束放射治疗后局部前列腺癌患者中使用细菌脱镁叶绿酸衍生物Tookad进行的血管靶向光动力疗法的首次临床应用。患者接受固定剂量的递增静脉药物剂量或最高光敏剂剂量的递增剂量光。将两个圆柱状扩散纤维经会阴放置在前列腺中，同时将光监测纤维放置在前列腺，尿道和直肠中。通过7天的T增强T1加权MRI和6个月的活检评估治疗反应。病变的形成强烈依赖于药物和光，并具有明显的阈值反应。早期的生化和MRI反应支持TOOKAD-PDT在治疗局部复发性前列腺癌方面的临床潜力。

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