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Photonic Hydrogel Beads for Controlled Release of Risedronate

机译：光子水凝胶微珠可控制释放Riseronate

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pH-sensitive photonic composite hydrogel beads composed of sodium alginate and risedronate sodium (SA/RIS) was prepared crosslinked by Ca~(2+) owing to the ionic gelation of SA. The structure and surface morphology of the composite hydrogel beads were characterized by SEM. pH-sensitivity of these composite hydrogels beads and the release behaviors of drug from them were investigated. The results showed that the composite hydrogel beads had good pH-sensitivity. The drug loading and encapsulation efficiency were 27.7% and 92% for RIS, respectively. The cumulative release ratios of RIS from the composite hydrogel beads were 2.47% in pH 2.1 solution and 83 % in pH 6.8 solutions within 24 h, respectively. However, the cumulative release ratio of RIS in pH 7.4 solution reached 91% within 7 h. It is proposed that the novel photonic SA/RIS composite hydrogel bead could possess the potential of an increased intestinal absorption and fewer adverse effects of RIS. The pH and salt response of photonic hydrogel bead, as well as the encapsulation of macromolecules, are promising for applications in biomedicine and biotechnology.
机译：通过SA〜（2+）的离子化作用，制备了由藻酸钠和利塞膦酸钠（SA / RIS）组成的pH敏感光子复合水凝胶珠。用SEM对复合水凝胶微珠的结构和表面形貌进行了表征。研究了这些复合水凝胶微珠的pH敏感性和药物从其中的释放行为。结果表明，复合水凝胶微珠具有良好的pH敏感性。 RIS的载药量和包封效率分别为27.7％和92％。 RIS在24小时内在pH 2.1溶液中的累积释放率为2.47％，在pH 6.8溶液中的累积释放率为83％。然而，RIS在pH 7.4溶液中的累积释放率在7 h内达到91％。有人提出，新型的光子SA / RIS复合水凝胶珠可以具有增加肠道吸收和减少RIS不良反应的潜力。光子水凝胶微珠的pH值和盐响应以及大分子的封装有望用于生物医学和生物技术。

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