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首页> 外文会议>Photonic therapeutics and diagnostics XI >Photoactive dye enhanced tissue ablation for endoscopic laser prostatectomy
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Photoactive dye enhanced tissue ablation for endoscopic laser prostatectomy

机译：光敏染料增强的组织切除术用于内镜激光前列腺切除术

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摘要

Laser light has been widely used as a surgical tool to treat benign prostate hyperplasia with high laser power. The purpose of this study was to validate the feasibility of photoactive dye injection to enhance light absorption and eventually to facilitate tissue ablation with low laser power. The experiment was implemented on chicken breast due to minimal optical absorption Amaranth (AR), black dye (BD), hemoglobin powder (HP), and endoscopic marker (EM), were selected and testedin vitro with a customized 532-nm laser system with radiant exposure ranging from 0.9 to 3.9 J/cm~2. Light absorbance and ablation threshold were measured with UV-VIS spectrometer and Probit analysis, respectively, and compared to feature the function of the injected dyes. Ablation performance with dye-injection was evaluated in light of radiant exposure, dye concentration, and number of injection. Higher light absorption by injected dyes led to lower ablation threshold as well as more efficient tissue removal in the order of AR, BD, HP, and EM. Regardless of the injected dyes, ablation efficiency principally increased with input parameter. Among the dyes, AR created the highest ablation rate of 44.2±0.2 μm/pulse due to higher absorbance and lower ablation threshold. Preliminary tests on canine prostate with a hydraulic injection system demonstrated that 80 W with dye injection yielded comparable ablation efficiency to 120 W with no injection, indicating 33 % reduced laser power with almost equivalent performance. In-depth comprehension on photoactive dye-enhanced tissue ablation can help accomplish efficient and safe laser treatment for BPH with low power application.
机译：激光已被广泛用作具有高激光功率的良性前列腺增生的外科手术工具。这项研究的目的是验证光敏染料注入以增强光吸收并最终以低激光功率促进组织消融的可行性。由于选择了最小的光吸收A菜（AR），黑色染料（BD），血红蛋白粉（HP）和内窥镜标记物（EM），因此对鸡胸肉进行了实验，并使用定制的532 nm激光系统在体外进行了测试。辐射暴露范围为0.9至3.9 J / cm〜2。分别使用UV-VIS光谱仪和Probit分析仪测量吸光度和烧蚀阈值，并将其与注入的染料的功能进行比较。根据辐射暴露，染料浓度和注入次数评估了染料注入的消融性能。注入的染料对光的吸收更高，导致消融阈值降低，并按AR，BD，HP和EM的顺序更有效地去除组织。不管注入的染料如何，消融效率主要随输入参数而增加。在这些染料中，由于较高的吸收度和较低的烧蚀阈值，AR产生的最高烧蚀速率为44.2±0.2μm/脉冲。通过液压注射系统对犬前列腺进行的初步测试表明，注射染料时80 W的烧蚀效率与不注射时的120 W相当，表明激光功率降低了33％，性能几乎相当。对光敏染料增强的组织消融的深入了解可以帮助以低功率应用完成对BPH的高效，安全的激光治疗。

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  • 来源
    《Photonic therapeutics and diagnostics XI》|2015年|93031D.1-93031D.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    Minwoo Ahn; Nguyen Trung Hau; Nguyen Van Phuc; Junghwan Oh; Hyun Wook Kang;

  • 作者单位

    Dept. of Biomedical Engineering, PKNU, Busan, Korea;

    Interdisciplinary Program of Marine-Bio, Electrical Mechanical Engineering, PKNU, Busan,Korea;

    Interdisciplinary Program of Marine-Bio, Electrical Mechanical Engineering, PKNU, Busan,Korea;

    Dept. of Biomedical Engineering, PKNU, Busan, Korea,Interdisciplinary Program of Marine-Bio, Electrical Mechanical Engineering, PKNU, Busan,Korea,Center for Marine-Integrated Biomedical Technology (BK21 Plus), PKNU, Busan, Korea;

    Dept. of Biomedical Engineering, PKNU, Busan, Korea,Interdisciplinary Program of Marine-Bio, Electrical Mechanical Engineering, PKNU, Busan,Korea,Center for Marine-Integrated Biomedical Technology (BK21 Plus), PKNU, Busan, Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Dye; Laser; Amaranth; Black Dye; Hemoglobin Powder; Endoscopic Marker;

    机译：染料;激光;苋菜;黑染料;血红蛋白粉；内窥镜标记;

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