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Determination of the pathological state of skin samples by optical polarimetry parameters

机译：用光学偏振法测定皮肤样品的病理状态

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摘要

Polarimetry is widely known to involve a series of powerful optical techniques that characterize the polarization behaviour of a sample. In this work, we propose a method for applying polarimetric procedures to the characterization of biological tissues, in order to differentiate between healthy and pathologic tissues on a polarimetric basis. Usually, medical morphology diseases are diagnosed based on histological alterations of the tissue. The fact that these alterations will be reflected in polarization information highlights the suitability of polarimetric procedures for diagnostic purposes. The analysis is mainly focused on the depolarization properties of the media, as long as the internal structure strongly affects the polarization state of the light that interacts with the sample. Therefore, a method is developed in order to determine the correlation between pathological ultraestructural characteristics and the subsequent variations in the polarimetric parameters of the backscattered light. This study is applied to three samples of porcine skin corresponding to a healthy region, a mole, and a cancerous region. The results show that the method proposed is indeed an adequate technique in order to achieve an early, accurate and effective cancer detection.
机译：旋光测定法众所周知，它涉及表征样品偏振行为的一系列强大的光学技术。在这项工作中，我们提出了一种将极化程序应用于生物组织表征的方法，以便在极化基础上区分健康组织和病理组织。通常，基于组织的组织学改变来诊断医学形态学疾病。这些改变将反映在极化信息中的事实突出了极化程序对诊断目的的适用性。只要内部结构强烈影响与样品相互作用的光的偏振态，分析就主要集中在介质的去偏振特性上。因此，开发了一种方法，以确定病理超结构特征与后向散射光的偏振参数的后续变化之间的相关性。这项研究适用于对应于健康区域，痣和癌变区域的三个猪皮肤样本。结果表明，提出的方法确实是一种适当的技术，可以实现早期，准确和有效的癌症检测。

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  • 来源
    《Photonics, devices, and systems IV》|2008年|71380I.1-71380I.6|共6页
  • 会议地点 Prague(CS)
  • 作者

    F. Fanjul-Velez; N. Ortega-Quijano; L. Buelta; J. L. Arce-Diego;

  • 作者单位

    Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Av. de los Castros S/N, 39005 Santander, Cantabria, Spain;

    Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Av. de los Castros S/N, 39005 Santander, Cantabria, Spain;

    Department of Medical and Surgery Sciences, University of Cantabria, Av. Herrera Oria S/N 39011 Santander, Cantabria, Spain;

    Applied Optical Techniques Group, Electronics Technology, Systems and Automation Engineering Department, University of Cantabria, Av. de los Castros S/N, 39005 Santander, Cantabria, Spain;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 工程光学;
  • 关键词

    polarimetry; depolarization factor; porcine skin cancer;

    机译：旋光法去极化因子猪皮肤癌;

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