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首页> 外文会议>Photonics, devices, and systems IV >Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions - two clinical cases
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Photodynamic detection in visualisation of cutaneous and oral mucosa premalignant and malignant lesions - two clinical cases

机译：光动力检测在皮肤和口腔粘膜癌变前和恶性病变可视化中的应用-两个临床案例

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Photodynamic diagnosis (PDD) is promising method of visualisation of premalignant and malignant lesions. PDD is rnconsisted of two main agents: special chemical compound which is called photosensitizer and light. Photosensitizer has rnaffinity to fast proliferating cells such as pre- or malignant. During light irradiation (with proper wavelength -rncorresponding to absorption peak of photosensitizer) photosensitizer gains energy and passes into excited singlet state S_1.rnReturning to basic singlet state S_n, leads to fluorescence. Due to difference between concentration of photosensitizer in rnlesion and normal tissue it is possible to obtain high contrast image of lesion.rnCase #1: 53 years old woman with basal cell carcinoma (BCC) in nasal region; 20% delta-aminolevulinic acid as a rnprecursor of photosensitizer on eucerin base was used. rnCase #2: 57 years old woman with multifocal oral leukoplakia on cheek mucosa and tongue; 2% chlorophyll gel as rnphotosesitizer was used.rnAll photographs were taken in white light without any filter and in blue and UV light with orange filter: in both cases the rntotal area of the lesions appeared to be larger than it has been clinically observed. Thus, the PDD might be helpful in rnevaluation of margins of surgical excision of such lesions.
机译：光动力诊断（PDD）是可视化的恶性前病变和恶性病变的方法。 PDD由两种主要成分组成：称为光敏剂的特殊化合物和光。光敏剂对快速增殖的细胞如恶性或恶性肿瘤没有亲和力。在光照射期间（具有适当的波长-n对应于光敏剂的吸收峰），光敏剂获取能量并进入激发单重态S_1。rn返回基本单重态S_n，导致荧光。由于病变和正常组织中光敏剂的浓度不同，因此可以获得较高的病变对比度图像。案例1：53岁的鼻区域有基底细胞癌（BCC）的女性；使用20％的δ-氨基乙酰丙酸作为光敏剂的前体，在Eucerin上。案例2：57岁的女性，颊黏膜和舌头患有多灶性口腔白斑；使用2％叶绿素凝胶作为光敏剂。所有照片均在不使用任何滤光片的白光下以及在使用橙色滤光片的蓝色和紫外光下拍摄：在两种情况下，皮损的总面积似乎大于临床观察到的面积。因此，PDD可能有助于重新评估此类病变的手术切除边缘。

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