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Photosensitizer fluorescence emission during Photodynamic Therapy applied to dermatological diseases

机译：光动力疗法在皮肤疾病中的光敏剂荧光发射

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Photodynamic Therapy (PDT) is an optical treatment modality that allows malignant tissue destruction. It is based on the administration of a photosensitizer and the posterior irradiation by an optical source. Photosensitizer molecules absorb the excitation light photons triggering a series of photochemical reactions in the presence of oxygen in the target tissue. During such interactions it is produced the de-excitation of the photosensitizer molecules in the singlet excited state which return to their minimum energy state by emitting fluorescence photons. These days, there are fixed clinical PDT protocols that make use of a particular optical dose and photosensitizer amount. However treatment response varies among patients and the type of pathology. In order to adjust an optimal dosimetry, the development of accurate predictive models plays an important role. The photosensitizer fluorescence can be used to estimate the degradation of the photoactive agent and as an implicit dosimetric measurement during treatment. However it is complex to know the fluorescence dependence with the depth in the tumor from observed fluorescence in the pathology surface. We present a first approach to predict the photosensitizer fluorescence dependence with depth during the PDT treatment applied to a skin disease commonly treated in the dermatological clinical practice. The obtained results permit us to know the photosensitizer temporal fluorescence evolution in different points of the tumor sample during the photochemical reactions involved in PDT with a predictive purpose related to the treatment evolution. The model presented also takes into account the distribution of a topical photosensitizer, the propagation of light in a biological media and the subsequent photochemical interactions between light and tissue. This implies that different parameters related with the photosensitizer distribution or the optical source characteristics could be adjusted to provide a specific treatment to a particular pathology.
机译：光动力疗法（PDT）是一种光学治疗手段，可以破坏恶性组织。它基于光敏剂的施用和光源的后照射。在目标组织中存在氧气时，光敏剂分子吸收激发光子，从而触发一系列光化学反应。在这种相互作用期间，产生了单重激发态的光敏剂分子的去激励，该光敏剂分子通过发射荧光光子而返回到其最小能量状态。如今，有固定的临床PDT协议可以利用特定的光剂量和光敏剂用量。但是，治疗反应因患者和病理类型而异。为了调整最佳剂量，准确的预测模型的开发起着重要的作用。光敏剂荧光可用于估计光敏剂的降解，并用作治疗期间的隐式剂量测量。然而，从病理表面观察到的荧光知道荧光随肿瘤深度的依赖性是很复杂的。我们提出了一种第一种方法来预测PDT治疗应用于皮肤病临床实践中通常治疗的皮肤疾病时，其深度对光敏剂荧光的依赖性。获得的结果使我们能够了解光敏剂在PDT参与的光化学反应过程中肿瘤样品不同点的时间荧光演化，其预测目的与治疗进展有关。提出的模型还考虑了局部光敏剂的分布，光在生物介质中的传播以及光与组织之间的后续光化学相互作用。这意味着可以调节与光敏剂分布或光源特性有关的不同参数，以对特定病理提供特定治疗。

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