首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >A high frame rate photoacoustic imaging system and its applications to perfusion measurements
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A high frame rate photoacoustic imaging system and its applications to perfusion measurements

机译:高帧率光声成像系统及其在灌注测量中的应用

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A high frame rate photoacoustic imaging system is described. Applications of this system to perfusion measurements are also presented as a demonstration of its potential usage. The system consists of an ultrasound front-end sub-system for acquisition of acoustic array data. The ultrasound front-end sub-system is also known as the DiPhAS (digital phased array system) which is capable of simultaneously acquiring radio frequency data from 64 transducer channels at a rate up to 40 MSamples/sec per channel. In this study, an ultrasonic linear array with a 5 MHz center frequency was employed as part of the integrated photoacoustic probe. The photoacoustic probe also had two linear light guides mounted on the sides of the ultrasonic array for broad laser irradiation from a Q-switched Nd:YAG pulsed laser. After the acquired ultrasound array data were transferred to a personal computer via a high speed digital I/Q card, dynamic focusing and image reconstruction were done off-line. The 64-channel array data can be acquired and transferred every 4 milliseconds, thus making the frame rate of the system up to 250 Hz. The actual frame rate of the current system is limited by the pulse repetition frequency of the laser at 15 Hz. To demonstrate capabilities of the system, photoacoustic perfusion measurements with gold nanorods were performed. A previously proposed time-intensity based flow estimation technique utilizing the shape transitions of gold nanorods under laser irradiation was employed. Good estimation results were achieved and potential of this high frame rate photoacoustic imaging system is clearly demonstrated.
机译:描述了高帧频光声成像系统。还介绍了该系统在灌注测量中的应用,以证明其潜在用途。该系统由超声前端子系统组成,用于采集声学阵列数据。超声前端子系统也称为DiPhAS(数字相控阵系统),它能够以每通道高达40 MSamples / sec的速率同时从64个换能器通道获取射频数据。在这项研究中,采用中心频率为5 MHz的超声线性阵列作为集成光声探头的一部分。光声探针还具有两个线性光导,这些线性光导安装在超声阵列的侧面,用于从调Q的Nd:YAG脉冲激光进行宽激光辐照。通过高速数字I / Q卡将获取的超声阵列数据传输到个人计算机后,离线进行动态聚焦和图像重建。每4毫秒就可以获取和传输64通道阵列数据,从而使系统的帧频高达250 Hz。当前系统的实际帧频受15 Hz的激光脉冲重复频率限制。为了演示该系统的功能,使用金纳米棒进行了光声灌注测量。使用先前提出的基于时间强度的流量估计技术,该技术利用金纳米棒在激光照射下的形状转变。获得了良好的估计结果,并且清楚地展示了这种高帧频光声成像系统的潜力。

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