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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2007; Progress in Biomedical Optics and Imaging; vol.8 no.14; Proceedings of SPIE-The International Society for Optical Engineering; vol.6437 >Deep reflection-mode photoacoustic imaging and resolution scalability with depth
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Deep reflection-mode photoacoustic imaging and resolution scalability with depth

机译：深度反射模式光声成像和深度分辨率可扩展性

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摘要

A deep reflection-mode photoacoustic (PA) imaging system was designed and implemented to visualize deep structures in biological tissues. To achieve good penetration depth, we chose near IR laser pulses at 804 nm wavelength for the generation of photoacoustic waves. To avoid overshadowing the deep PA signals by the surface PA signals, we employed dark-field illumination. To achieve good lateral resolution, we chose spherically focused high-numericalaperture ultrasonic transducers with 5 MHz or 10 MHz center frequencies. By using these transducers, we achieved 153 μm and 130 μm axial resolutions, respectively, at 19.5 mm depth in 10% porcine gelatin containing 1% intralipid. The system was applied to imaging internal organs of small animals. Compared with our previous high-frequency (50-MHz) photoacoustic microscope, we scaled up the imaging depth while maintaining the ratio of the imaging depth to axial resolution more than 100. In addition, we studied the scalability of the imaging depth and the resolution with ultrasound frequency.
机译：设计并实施了深反射模式光声（PA）成像系统，以可视化生物组织中的深层结构。为了获得良好的穿透深度，我们选择波长为804 nm的近红外激光脉冲来产生光声波。为了避免深PA信号被表面PA信号遮盖，我们采用了暗场照明。为了获得良好的横向分辨率，我们选择了中心频率为5 MHz或10 MHz的球形聚焦高数值孔径超声换能器。通过使用这些换能器，在含1％脂质的10％猪明胶中，在19.5 mm的深度下，我们分别获得了153μm和130μm的轴向分辨率。该系统用于对小动物的内脏进行成像。与我们以前的高频（50-MHz）光声显微镜相比，我们在保持成像深度与轴向分辨率之比超过100的同时扩大了成像深度。此外，我们还研究了成像深度和分辨率的可扩展性超声频率。

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