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首页> 外文会议>Physiology, Function, and Structure from Medical Images pt.2; Progress in Biomedical Optics and Imaging; vol.6, no.23 >Neurocognitive correlates of white matter in children surviving cancer: A quantitative MR imaging study
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Neurocognitive correlates of white matter in children surviving cancer: A quantitative MR imaging study

机译：癌症幸存儿童中白质的神经认知相关性：MR定量成像研究

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Due to the inherent risk of central nervous system (CNS) dissemination, children treated for either acute lymphoblastic leukemia (ALL) or malignant brain tumors (BT) receive aggressive CNS therapy. The primary objective of this study was to confirm a previously observed association between reduced volumes of normal-appearing white matter (NAWM) and intellectual and attentional deficits in survivors. A combined MR imaging set consisting of T1, T2, and PD images were collected for 221 children (110 BT; 112 ALL). MR imaging sets were segmented with a hybrid neural network algorithm and volumetric measurements were calculated for five slices centered on the basal ganglia. Summary measures of Overall Index, Omissions, d' (attentiveness), and beta (risk-taking) were derived from the computer-administered Conners' Continuous Performance Test (CPT). Age-corrected estimates of Full-Scale IQ (FSIQ) were also obtained. Pearson correlation analyses were performed between each neurocognitive measure and the volume of NAWM. The correlation between FSIQ and NAWM failed to reach statistical significance for the BT group but was highly significant for the more homogeneous ALL group. Larger Omission rates, decreased attentiveness and more risk taking were significantly associated with lower NAWM volumes in both groups of survivors. Long-term survivors are at increased risk for cognitive delays or deficits, which oftentimes impair future academic performance, employment, and quality of life. These long-term adverse effects of treatment appear to be due to a diminished ability to acquire new information and may be secondary to deficits in attention, which is thought to be supported by interhemispheric and intrahemispheric white matter tracts.
机译：由于传播中枢神经系统（CNS）的固有风险，接受急性淋巴细胞白血病（ALL）或恶性脑瘤（BT）治疗的儿童会接受积极的CNS治疗。这项研究的主要目的是确认先前观察到的正常出现的白质（NAWM）减少与幸存者智力和注意力缺陷之间的关联。为221名儿童（110 BT； 112 ALL）收集了由T1，T2和PD图像组成的组合MR成像集。用混合神经网络算法对MR成像集进行分割，并计算以基底神经节为中心的五个切片的体积测量值。综合指数，遗漏，d'（专心）和beta（冒险）的汇总量度来自计算机管理的Conners持续绩效测试（CPT）。还获得了年龄校正的全智商（FSIQ）估计。在每个神经认知指标和NAWM量之间进行Pearson相关分析。 FSIQ和NAWM之间的相关性对于BT组未能达到统计学显着性，但对于更均一的ALL组则具有高度显着性。两组幸存者中较高的遗漏率，专注力下降和更多的冒险行为与较低的NAWM量显着相关。长期幸存者面临认知迟缓或缺陷的风险增加，这常常会损害未来的学业成绩，就业和生活质量。这些长期的治疗不良反应似乎是由于获取新信息的能力下降而引起的，并且可能是注意力缺乏的继发原因，注意力缺乏被认为是由半球间和半球内白质区支持的。

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