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首页> 外文会议>Plasma for bio-decontamination, medicine and food security >Antisepsis of the Skin by Treatment with Tissue-Tolerable Plasma (TTP): Risk Assessment and Perspectives
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Antisepsis of the Skin by Treatment with Tissue-Tolerable Plasma (TTP): Risk Assessment and Perspectives

机译：组织耐受性血浆（TTP）治疗皮肤的防腐作用：风险评估和观点

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摘要

The application of tissue tolerable plasma (TTP) is well suited for disinfection of living tissue. In particular, when treating chronic wounds, it has several advantages in comparison to the classical application of antiseptics, which do not penetrate sufficiently into the tissue or inhibit wound regeneration. The mode of action of the plasma is mainly based on synergetic effects between temperature increase and the formation of free radicals, which destroy the bacteria and fungi. In the present paper a risk assessment of TTP in dermatology is given. The investigations have been carried out with an atmospheric pressure plasma-jet working with Argon as a discharge medium. It was found that during the plasma treatment of tissue, the antioxidative potential is reduced only in the upper part of the stratum corneum, but not in deeper cell layers. Selecting the optimum parameters of the plasma formation, the UV exposure of the skin is less than in the case of UV irradiation of the sun on a summer day at noon. If the duration of the plasma treatment of the skin is in the optimal range for wound healing, no thermal damage has to be expected. Additionally, it could be demonstrated that plasma is able to reach the follicular reservoir for antisepsis where germs are located.
机译：组织耐受血浆（TTP）的应用非常适合对活体组织进行消毒。特别是，在治疗慢性伤口时，与传统的抗菌剂相比，它具有多个优点，而传统的抗菌剂不能充分渗透到组织中或抑制伤口再生。血浆的作用方式主要基于温度升高和自由基的形成之间的协同作用，自由基会破坏细菌和真菌。在本文中，对皮肤病中TTP的风险进行了评估。该研究是通过使用氩气作为放电介质的大气压等离子体射流进行的。发现在对组织进行等离子体处理期间，抗氧化电位仅在角质层的上部降低，而在较深的细胞层中并未降低。选择等离子体形成的最佳参数，皮肤的紫外线暴露要小于夏日中午的阳光紫外线照射。如果皮肤的等离子治疗的持续时间在伤口愈合的最佳范围内，则无需热损伤。另外，可以证明血浆能够到达细菌所在的用于防腐的卵泡储层。

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  • 来源
  • 会议地点 Demanovska Dolina(SK)
  • 作者

    Juergen Lademann; Heike Richter; Alexa Patzelt; Martina C. Meinke; Joachim W. Fluhr; Axel Kramer; Klaus-Dieter Weltmann; Olaf Lademann;

  • 作者单位

    Department of Dermatology and Allergology, Charite - Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany;

    Department of Dermatology and Allergology, Charite - Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany;

    Department of Dermatology and Allergology, Charite - Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany;

    Department of Dermatology and Allergology, Charite - Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany;

    Department of Dermatology and Allergology, Charite - Universitaetsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany;

    Institute of Hygiene and Environmental Medicine, Ernst-Moritz-Arndt University, Walther-Rathenau-Str. 49a, Greifswald, Germany;

    Department of Internal Medicine, Helios Klinik, Bad Saarow, Germany Leibniz Institute for Plasma Science and Technology e. V. (INP Greifswald), Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany;

    Institute of Hygiene and Environmental Medicine, Ernst-Moritz-Arndt University, Walther-Rathenau-Str. 49a, Greifswald, Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学（生物技术）;
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