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Cellulose Nanocrystals for Drug Delivery

机译：用于药物递送的纤维素纳米晶体

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摘要

Since the first investigation of liposomes as drug carrier systems in chemotherapy, nanoscale carrier systems have attracted increasing attention in therapeutic and diagnostic medicine. Cellulose nanocrystals have attractive properties as nanoscale carriers for bioactive molecules in biomedical applications. To test whether cellulose nanocrystals could be used as carriers in the targeted delivery of therapeutics, their toxicity to human brain microvascular endothelial cells was measured. Cellulose nanocrystals were found to be non-toxic to the cells. For cellular uptake studies, cellulose nanocrystals were labeled with fluorescein-5'-isothiocyanate. The uptake studies showed minimal uptake of untargeted cellulose nanocrystals. The lack of toxicity and untargeted uptake support the potential of cellulose nanocrystals as carriers in targeted drug delivery applications.
机译：自从脂质体作为化学疗法中的药物载体系统的首次研究以来，纳米级载体系统已在治疗和诊断医学中引起越来越多的关注。纤维素纳米晶体作为生物医学应用中生物活性分子的纳米级载体具有吸引人的特性。为了测试纤维素纳米晶体是否可以用作靶向治疗药物的载体，测定了其对人脑微血管内皮细胞的毒性。发现纤维素纳米晶体对细胞无毒。为了进行细胞摄取研究，用荧光素5'-异硫氰酸酯标记纤维素纳米晶体。吸收研究表明，未靶向的纤维素纳米晶体的吸收最小。毒性的缺乏和未靶向的吸收支持了纤维素纳米晶体在靶向药物递送应用中作为载体的潜力。

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  • 会议地点 Chicago IL(US)
  • 作者

    Maren Roman; rnShuping Dong; rnAnjali Hirani; rnYong Woo Lee;

  • 作者单位

    Macromolecules and Interfaces Institute and Department of Wood Science and Forest Products, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

    rnMacromolecules and Interfaces Institute and Department of Wood Science and Forest Products, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

    rnDepartment of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

    rnDepartment of Biomedical Sciences and Pathobiology, School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

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  • 正文语种 eng
  • 中图分类 有机质材料;
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