High Throughput Screening Method for Determination of Equilibrium Drug solubility

机译：高通量筛选方法测定药物的平衡溶解度

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Using a UV platereader, multichannel pipettes and disposable 96-well plates, we have developed a method which allows high throughput screening of the equilibrium solubility of drugs in aqueous media. The method was developed as part of an effort to evaluate the potential of hydroxybutenyl-p-cyclodextrin (HBenCD) for the delivery of poorly soluble drugs. This method differs from other reported high throughput screening methods in that thermodynamic or equilibrium solubility is measured at greatly increased throughput and without the use of an organic solvent. Conservatively a 100 fold increase in test throughput can be achieved. Additionally, a high throughput method for measuring solution stability was developed.

机译：我们使用UV读板仪，多通道移液器和一次性96孔板开发了一种方法，该方法可以高通量筛选药物在水性介质中的平衡溶解度。该方法的开发是评估羟基丁烯基对环糊精（HBenCD）递送难溶性药物的潜力的一部分。该方法与其他报道的高通量筛选方法的不同之处在于，在不使用有机溶剂的情况下，以大大提高的通量测量了热力学或平衡溶解度。保守地，可以将测试吞吐量提高100倍。另外，开发了用于测量溶液稳定性的高通量方法。

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《Polysaccharide materials: Performance by design》|2007年|P.65-80|共16页
会议地点 Chicago IL(US)
作者
Norma L. Buchanan; rnCharles M. Buchanan;
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Eastman Chemical Company, Research Laboratories, P.O. Box 1972, Kingsport, TN 37662, USA;

rnEastman Chemical Company, Research Laboratories, P.O. Box 1972, Kingsport, TN 37662, USA;

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正文语种 eng
中图分类有机质材料;
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2. Comparison of Nephelometric, UV-Spectroscopic, and HPLC Methods for High-Throughput Determination of Aqueous Drug Solubility in Microtiter Plates [J] . Bettina Hoelke, Sabine Gieringer, Michael Arlt, Analytical chemistry . 2009,第8期

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3. Development of a high throughput equilibrium solubility assay using miniaturized shake-flask method in early drug discovery. [J] . Zhou L, Yang L, Tilton S, Journal of pharmaceutical sciences. . 2007,第11期

机译：在早期药物发现中开发了使用小型摇瓶法的高通量平衡溶解度测定法。
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High Throughput Screening Method for Determination of Equilibrium Drug solubility

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