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Modification of the crystallographic structure of olanzapine during solvation by PALS and X-ray diffraction methods

机译:通过PALS和X射线衍射方法修饰奥氮平在溶剂化过程中的晶体学结构

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摘要

Two selected solvents were incorporated into the olanzapine structure. Molecules located inside the voids in the structure caused the changing of the o-Ps lifetime and intensity. After removing the n-butanol·H_2O molecules, the materials returned to its initial structure. Creating the complex with the methanol·H_2O leads to the change of the crystallographic structure of the olanzapine.
机译:将两种选择的溶剂掺入奥氮平结构中。位于结构空隙中的分子导致了o-Ps寿命和强度的变化。除去正丁醇·H_2O分子后,材料返回其初始结构。用甲醇·H_2O生成配合物会导致奥氮平的晶体结构发生变化。

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  • 来源
  • 会议地点 Smolenice Castle(SK)
  • 作者单位

    Institute of Physics, Maria Curie Sklodowska University, PI. Marii Curie Sklodowskiej 1, 20-031 Lublin, Poland;

    Institute of Physics, Maria Curie Sklodowska University, PI. Marii Curie Sklodowskiej 1, 20-031 Lublin, Poland;

    Faculty of Chemistry, Maria Curie Sklodowska University, PI. Marii Curie Sklodowskiej 3, 20-031 Lublin, Poland;

    Faculty of Chemistry, Maria Curie Sklodowska University, PI. Marii Curie Sklodowskiej 3, 20-031 Lublin, Poland;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    positron annihilation; free volume; olanzapine; solvent; solvates;

    机译:正电子an灭自由体积;奥氮平溶剂;溶剂化物;

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