首页> 外文会议>Proceedings of the 11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems >Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells
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Capillary number effect on the depletion of leucocytes of blood in microfiltration chips for the isolation of circulating tumor cells

机译:毛细管数对微滤芯片中血液白细胞耗竭的影响,用于分离循环肿瘤细胞

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摘要

To increase the purity of isolated circulating tumor cells (CTCs) in microfiltration chips, the depletion of leucocytes in human blood was systematically studied as a function of two dimensionless parameters, Capillary number Ca and the normalized leucocyte diameter. An optimized Ca* of 0.038 was identified to differentiate the capturing of cancer cells and leucocytes. Such Ca effect can be applied as a guideline for designing an optimized microfiltration system with both high capture efficiency and purity for isolating CTCs from human blood.
机译:为了提高微滤芯片中分离的循环肿瘤细胞(CTC)的纯度,系统地研究了人血中白细胞的消耗,这是两个无量纲参数,毛细管数Ca和归一化白细胞直径的函数。确定最佳的Ca *为0.038,以区分癌细胞和白细胞的捕获。这种Ca效应可以用作设计优化的微滤系统的指南,该系统具有高捕获效率和高纯度,可从人血中分离CTC。

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