The Complementary Role of Calorimetry, Thermal Gravimetry and Variable Environmental Conditions X-ray Diffraction in Pharmaceutical Sciences

机译：热量测定法，热重分析法和可变环境条件X射线衍射在药物科学中的补充作用

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

The obvious application for calorimetry and TG is to monitor and characterize phaserntransformations. It is in this capacity that calorimetry finds its great application inrnpharmaceutical sciences. There are several stages in drug development, taking on average 8-rn12 years, which call for a precise knowledge of a potential phase transition occurring in eitherrndrug substance or a drug product. The thermal techniques themselves often come short inrndelivering sufficient information or experimental discriminating power to satisfy the need ofrnregulatory requirements or process control. In these cases thermal techniques play a guidingrnrole to predefine experimental conditions to apply other techniques like x-ray diffraction, IRrnor Raman spectroscopy applied at various environmental conditions. Often DVS needs to bernused to specify the environmental conditions more.rnIn this talk we will identify several areas in drug development process, which call forrnuse of thermal techniques. We will also demonstrate how thermal techniques can guide andrnsupplement, IR, Raman and DVS and x-ray diffraction, the most definitive technique tornestablish a presence of a polymorph or a solvate. We will discuss significance of therninformation generated by thermal techniques alone and in combination with other techniquesrnto the drug development process.

机译：量热法和TG的明显应用是监视和表征相变。量热法正是以此身份在制药科学中找到了重要的应用。药物开发有多个阶段，平均需要8-12年，这需要对药物物质或药物产品中可能发生的潜在相变有确切的了解。热技术本身往往不足以提供足够的信息或实验区分能力，以满足监管要求或过程控制的需要。在这些情况下，热技术扮演着指导角色，可以预定义实验条件，以应用其他技术，例如在各种环境条件下应用的X射线衍射，IRrnor拉曼光谱。通常，需要调动DVS来详细说明环境条件。在本次演讲中，我们将确定药物开发过程中的几个领域，这些领域要求废止热技术。我们还将演示热技术如何引导和补充，IR，拉曼和DVS和X射线衍射，这是最确定的技术，可以确定存在多晶型物或溶剂化物。我们将讨论单独通过热学技术以及与其他技术结合产生的热信息对药物开发过程的意义。

著录项

来源
《Proceedings of the 31st annual conference of the North American Thermal Analysis Society(NATAS)》|2003年|p.1|共1页
会议地点 Albuquerque NM(US);Albuquerque NM(US);Albuquerque NM(US)
作者
Angeline Zakrzewski;
展开▼
作者单位

ASSA International Inc. Danbury , CT;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类热学;
关键词

相似文献

外文文献
中文文献
专利

1. Simultaneous measurements of X-ray diffraction (XRD) and differential scanning calorimetry (DSC) data under controlled humidity condition: Instrumentation and application to studies on hydration, dehydration, and rehydration processes of pharmaceutical [J] . A. Kishi, H. Toraya Powder diffraction . 2004,第1期

机译：在受控湿度条件下同时测量X射线衍射（XRD）和差示扫描量热法（DSC）数据：仪器和在药物的水合，脱水和再水化过程研究中的应用
2. Simultaneous Differential Scanning Calorimetry-Synchrotron X-ray Powder Diffraction: A Powerful Technique for Physical Form Characterization in Pharmaceutical Materials [J] . Clout Alexander, Buanz Asma B. M., Prior Timothy J., Analytical chemistry . 2016,第20期

机译：同步差示扫描量热法-同步加速器X射线粉末衍射：药物材料物理形态表征的强大技术
3. Polymorphs of p-nitrophenol as studied by variable-temperature X-ray diffraction and calorimetry: comparison with m-nitrophenol. [J] . Wojcik G, Mossakowska I Acta Crystallographica, Section B. Structural Science . 2006,第1期

机译：通过可变温度X射线衍射和量热法研究的对硝基苯酚的多晶型物：与间硝基苯酚的比较。
4. The Complementary Role of Calorimetry, Thermal Gravimetry and Variable Environmental Conditions X-ray Diffraction in Pharmaceutical Sciences [C] . Angeline Zakrzewski Annual conference of the NATAS . 2003

机译：热量测定法，热重定量和可变环境条件在制药中的互补作用X射线衍射
5. Green technology towards pharmaceutical drug development: I. Synthesis of differentially functionalized hydroquinone as an important pharmaceutical intermediate. II. Application in green chemistry: Environmentally friendly cleavage of aromatic ethers and trans-etherification under neutral conditions. III. Environmentally friendly simple amidation of nitro compounds: One step synthesis of acetaminophen. [D] . Tichkule, Ritesh. 2004

机译：面向药物开发的绿色技术：I.合成功能不同的对苯二酚作为重要的药物中间体。二。在绿色化学中的应用：在中性条件下对芳族醚进行环境友好的裂解和反式醚化。三，硝基化合物的环保简单酰胺化：对乙酰氨基酚的一步合成。
6. Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction. [O] . H Chung, M Caffrey 1992

机译：通过同时量热法和时间分辨X射线衍射建立的水合脂质中结构变化和热事件的直接相关性。
7. Analysis of thermal degradation in Nylon 66 by X-ray photoelectron spectrometry, X-ray diffraction and differential scanning calorimetry. [O] . Yushi SHICHI, Yasuhide INOUE, Masaharu ARITA, 1990

机译：X射线光电子光谱法，X射线衍射和差示扫描量热法分析尼龙66的热降解。

The Complementary Role of Calorimetry, Thermal Gravimetry and Variable Environmental Conditions X-ray Diffraction in Pharmaceutical Sciences

摘要

著录项

相似文献

相关主题

期刊订阅