Isolation and Total Synthesis and Antiviral Activity of Alkaloids from Cynanchum Komarovii and an Innovative Research for Novel Antiplant Viral Agent NK-007

机译：虎杖生物碱的分离，全合成及抗病毒活性及新型抗植物病毒制剂NK-007的创新研究

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

@@ In a program aimed at screening of plants for biologically active natural products as alternatives to conventional synthetic agrochemicals, we have found that an alcohol extract of Cynanchum komarovii shows antiviral activity against tobacoo mosaic virus. Using a bioassay directed fractionation approach, we have found that the portion of alkaloid is the main active component and antofine is the primary content of the alkaloid. Bioassay results showed that antofine exhibited 60% inhibition against TMV at a concentration of 1. 0 μg/ mL, which was 10-100 times more active than all of reported plant virus inhibitors.

机译：@@@@@@@@@@@@@@@@@@@@@@@@@的程序，旨在筛选具有生物活性的天然产物的植物，作为常规合成农业化学药品的替代品，我们发现Cynanchum komarovii的醇提取物对烟草花叶病毒具有抗病毒活性。使用生物测定定向分馏方法，我们发现生物碱的部分是主要活性成分，而antofine是生物碱的主要成分。生物测定结果表明，antofine在1. 0μg/ mL的浓度下对TMV表现出60％的抑制作用，其活性是所有报道的植物病毒抑制剂的10-100倍。

著录项

来源
《Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization》|2012年|280-281|共2页
会议地点 Beijing(CN)
作者
Qingmin Wang;
展开▼
作者单位

Prof. Dr. Qingmin Wang, State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University,Tianjin 300071, People's Republic of China;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类植物化学保护理论;农用化学物质、有毒化学物质污染及其防治;
关键词
Cynanchum komarovii; isolation; total synthesis; antiviral activity; NK-007;

机译：虎杖；分离；总合成；抗病毒活性； NK-007;

相似文献

外文文献
中文文献
专利

1. Alkaloids from Cynanchum komarovii with inhibitory activity against thetobacco mosaic virus [J] . An TY, Huang RQ, Yang Z, Phytochemistry . 2001,第8期

机译：虎杖生物碱对烟草花叶病毒具有抑制作用
2. Insecticidal and antifeedant effects of two alkaloids from Cynanchum komarovii against larvae of Plutella xylostella L. [J] . Guo H., Yang M., Qi Q. Journal of Applied Entomology . 2014,第1a2期

机译：虎杖两种生物碱对小菜蛾幼虫的杀虫和拒食作用。
3. Optimisation of conditions for extracting pesticidal alkaloids from Cynanchum komarovii (Maxim.) [J] . CongaiZ., YanyanG., XuechangZ., Natural product research . 2013,第1a3期

机译：优化从香附子中提取农药生物碱的条件（最大）
4. Isolation and Total Synthesis and Antiviral Activity of Alkaloids from Cynanchum Komarovii and an Innovative Research for Novel Antiplant Viral Agent NK-007 [C] . Qingmin Wang International workshop on crop protection chemistry and regulatory harmonization . 2012

机译：Cynanchum Komarovii中生物碱的分离和总合成及抗病毒活性以及新型抗持续病毒剂NK-007的创新研究
5. Part I: The first regio- and atropdiastereoselective total synthesis of the dimeric indole alkaloid (+)-dispegatrine, as well as the first total synthesis of the sarpagine alkaloids (+)-spegatrine, lochvinerine, (+)-lochneram and an improved total synthesis of (+)-10-methoxyvellosimine, (+)-lochnerine and (+)-sarpagine. Part II: Studies directed toward the total synthesis of the carbon-19 methyl substituted sarpagine-macroline alkaloids (+)-macro-salhine chloride as well as macrocarpine A, B and C. [D] . Edwankar, Chitra R. 2011

机译：第一部分：二聚吲哚生物碱（+）-dispegatrine的第一个区域和对映异构选择性全合成，以及sarpagine生物碱（+）-spegatrine，lochvinerine，（+）-lochneram的第一个全合成（+）-10-甲氧基玻璃素胺，（+）-氯精胺和（+）-sarpagine的合成。第二部分：研究碳19甲基取代的沙雷帕金-大麦碱生物碱（+）-大-沙丁鱼碱氯化物以及大芸香碱A，B和C的总合成。
6. Synthesis and Biological Evaluation of Epidithio- Epitetrathio- and bis-(Methylthio)diketopiperazines. Synthetic Methodology Enantioselective Total Synthesis of Epicoccin G 88′-epi-ent-Rostratin B Gliotoxin Gliotoxin G Emethallicin E and Haematocin and Discovery of New Antiviral and Antimalarial Agents [O] . K. C. Nicolaou, Min Lu, Sotirios Totokotsopoulos, -1

机译：合成和Epidithio-Epitetrathio-的生物学评价并 - （甲硫基）二酮哌嗪。合成方法Epicoccin的G不对称全合成88--EpI-ENT-Rostratin B胶霉毒素胶霉毒素GEmethallicin E和Haematocin以及新的抗病毒和抗疟药的发现
7. Purification and Characterization of a CkTLP Protein from Cynanchum komarovii Seeds that Confers Antifungal Activity [O] . Wang, Qinghua, Li, Fuguang, Zhang, Xue, 2011

机译：拟南芥CkTLP蛋白的纯化和鉴定赋予抗真菌作用的Cylanchum komarovii种子活动

Isolation and Total Synthesis and Antiviral Activity of Alkaloids from Cynanchum Komarovii and an Innovative Research for Novel Antiplant Viral Agent NK-007

摘要

著录项

相似文献

相关主题

期刊订阅