Design of Novel Molting Hormone Agonists/Antagonists

机译：新型蜕皮激素激动剂/拮抗剂的设计

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@@ Insects grow by repetitively molting, a process that is regulated by a molting hormone, 20hydroxyecdysone (20E)，acting on the ecdysone receptor (EcR). Compounds that are antagonists of 20E binding to EcR are therefore candidates for insecticides. Among them, diacylhydrazine (DAH)-type compounds that mimic the action of 20E have been developed to control insect populations, and several DAHs (tebufenozide, methoxyfenozide, halofenozide, fufenozide, and chromafenozide) are in regular agricultural use worldwide. Most of these DAHs are potent only against Lepidoptera, and not against other insect orders, while halofenozide is used not only for Lepidoptera but also for the Coleptera pests.

机译：@昆虫通过反复蜕皮而生长，该过程受蜕皮激素受体（EcR）作用的蜕皮激素20羟基蜕皮激素（20E）调节。因此，作为20E与EcR结合的拮抗剂的化合物是杀虫剂的候选物。其中，已开发出模仿20E作用的二酰基肼（DAH）型化合物来控制昆虫种群，并且在世界范围内常规农业中使用了几种DAH（戊苯乙酰胺，甲氧苯芬唑，氟苯乙脲，氟苯乙酰胺和苯甲酰肼）。这些DAH中的大多数仅对鳞翅目有效，而对其他昆虫无害，而氟苯乙脲不仅用于鳞翅目，而且也用于Colleptera害虫。

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来源
《Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization》|2012年|379|共1页
会议地点 Beijing(CN)
作者
Yoshiaki Nakagawa;
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作者单位

Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan;

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会议组织
原文格式 PDF
正文语种 eng
中图分类植物化学保护理论;农用化学物质、有毒化学物质污染及其防治;
关键词
In silico screening; molting; ecdysone; diacylhydrazine; ponasterone;

机译：计算机筛选；蜕皮；蜕皮激素；二酰肼； pon甾酮;

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机译：使用表达各种昆虫蜕皮激素受体的酵母来检测天然和合成蜕皮激素激动剂的新报告基因测定法
4. Design of Novel Molting Hormone Agonists/Antagonists [C] . Yoshiaki Nakagawa International workshop on crop protection chemistry and regulatory harmonization . 2012

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机译：cHYD1溶液相合成的优化及新型人生长激素拮抗剂和激动剂的研制
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机译：重组卵泡促性腺激素，重组黄体生成激素或促性腺激素释放激素（GnRH）激动剂给药后，在体外受精患者中接受重组卵泡刺激素和GnRH拮抗剂联合卵巢刺激后卵母细胞成熟，黄体期特征未得到补充

Design of Novel Molting Hormone Agonists/Antagonists

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