New Approach to Harmonized Guidelines for Endocrine Disrupter Testing and Assessment

机译：内分泌干扰物测试和评估统一指南的新方法

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@@ A variety of chemicals including pesticides and their metabolites have been suspected of exerting adverse effects on humans and/or wild life based on their endocrine activities since an endocrine disrupter issue arose in the last decade of the 20th century. Typical examples are organochlorine pesticides such as DDT, DDE and methoxychlor. Suspected adverse effects of endocrine disrupters diverge widely; thus regulators and health advocates are seriously concerned for developmental and reproductive toxicities, immunotoxicity, neurotoxicity and/or carcinogenicity of these pesticides based on their estrogenic and/or antiandrogenic properties.

机译：自从20世纪最后十年出现内分泌干扰物以来，就已经怀疑包括农药及其代谢产物在内的多种化学物质会基于其内分泌活动对人类和/或野生生物产生不利影响。典型的例子是有机氯农药，如DDT，DDE和甲氧氯。怀疑内分泌干扰物的不良反应差异很大。因此，基于这些农药的雌激素和/或抗雄激素特性，监管者和健康倡导者对这些农药的发育和生殖毒性，免疫毒性，神经毒性和/或致癌性感到严重关注。

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来源
《Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization》|2012年|41|共1页
会议地点 Beijing(CN)
作者
Hiroaki Aoyama;
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作者单位

Toxicology Division, Institute of Environmental Toxicology, Joso, Japan;

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会议组织
原文格式 PDF
正文语种 eng
中图分类植物化学保护理论;农用化学物质、有毒化学物质污染及其防治;
关键词
estrogenic; anti-androgenic; tiered approach; screening assay; definitive test;

机译：雌激素;抗雄激素;分层方法;筛选试验;确定性试验;

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专利

1. An Assessment of Endocrine Disruption in Mollusks and the Potential for Developing Internationally Standardized Mollusk Life Cycle Test Guidelines [J] . Peter Matthiessen Integrated environmental assessment and management . 2008,第3期

机译：软体动物内分泌干扰的评估和制定国际标准化软体动物生命周期测试指南的潜力
2. An Assessment of Endocrine Disruption in Mollusks and the Potential for Developing Internationally Standardized Mollusk Life Cycle Test Guidelines [J] . Peter Matthiessen Integrated Environmental Assessment and Management . 2008,第3期

机译：软体动物内分泌干扰的评估和制定国际标准化软体动物生命周期测试指南的潜力
3. Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment [J] . EFSA Journal . 2013,第3期

机译：关于内分泌干扰物危险性评估的科学意见：鉴定内分泌干扰物的科学标准以及评估这些物质对人类健康和环境影响的现有测试方法的适当性
4. New Approach to Harmonized Guidelines for Endocrine Disrupter Testing and Assessment [C] . Hiroaki Aoyama International workshop on crop protection chemistry and regulatory harmonization . 2012

机译：统一内分泌失价试验和评估指南的新方法
5. Steroid-mimics in Anurans: Comparative assessments of the "endocrine disruptor" hypothesis. [D] . Noriega, Nigel Cassius. 2001

机译：Anurans中的类固醇模拟物：“内分泌干扰物”假说的比较评估。
6. Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project [O] . Diana M Merino, Lisa M McShane, David Fabrizio, 2020

机译：建立协调一致的肿瘤突变负担（TMB）的指南：计算机诊断跨诊断平台的TMB定量变化：癌症之友研究TMB协调项目的第一阶段
7. OECD Conceptual Framework for Testing and Assessment of Endocrine Disrupters as a basis for regulation of substances with endocrine disrupting properties [O] . 2004

机译：经合组织内分泌干扰物测试和评估概念框架，作为管制具有内分泌干扰物的物质的基础

New Approach to Harmonized Guidelines for Endocrine Disrupter Testing and Assessment

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