Harmonized Approach to Future Toxicology Testing for Pesticide Regulation

机译：协调未来农药毒理学测试的方法

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@@ There are 4 major view points to guarantee safety of pesticides: (1) Phyto-toxicity, (2) Operator∏s health, (3) Consumer ∏ s health, and (4) Ecotoxicity. In order to minimize risk on human health from unexpected exposure, a huge volume of toxicological should be prepared through various toxicity studies. Acute toxicity studies via oral/dermal/inhalation routes, eye/dermal irritation studies, and dermal sensitization studies are mainly focused on Point 2. For the Point 3, sub-chronic and chronic repeated oral toxicity studies, reproduction toxicity studies, and carcinogenicity studies are designed to evaluate toxicity for lifespan, transplacental and multi-generation exposure. Genotoxicity data helps to interpret the carcinogenity is primary or secondary.

机译：@@有四个主要观点可保证农药的安全性：（1）植物毒性，（2）操作人员的健康，（3）消费者的健康，以及（4）生态毒性。为了将意外暴露对人体健康的风险降至最低，应通过各种毒性研究制备大量的毒理学物质。通过口服/皮肤/吸入途径进行的急性毒性研究，对眼睛/皮肤的刺激性研究以及皮肤致敏性研究主要集中在第2点。对于第3点，亚慢性和慢性反复口腔毒性研究，生殖毒性研究和致癌性研究用于评估寿命，胎盘和多代暴露的毒性。遗传毒性数据有助于解释致癌性是原发性还是继发性。

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《Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization》|2012年|49|共1页
会议地点 Beijing(CN)
作者
Kosei Inui;
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作者单位

Central Research Institute, Ishihara Sagyo Kaisha, Ltd.;

Kusatsu, Japan;

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会议组织
原文格式 PDF
正文语种 eng
中图分类植物化学保护理论;农用化学物质、有毒化学物质污染及其防治;
关键词
toxicity studies; harmonization; GLPs; test guidelines;

机译：毒性研究;协调; GLP;测试指南;

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1. Harmonization and toxicological classification of pesticides in 1992 in Brazil and the need to foresee the impacts from the forthcoming introduction of GHS [J] . Bussacos Marco Antonio, Fischer Frida Marina, Garcia Eduardo Garcia Ciencia e Saude Coletiva . 2008,第2008期

机译：巴西于1992年对农药进行了协调和毒理学分类，还需要预见即将推出的GHS所产生的影响
2. EPA Grapples With New Methods To Harmonize Pesticide, Water Risk Tests [J] . Bridget DiCosmo Inside EPA's environmental policy alert . 2010,第25期

机译：EPA努力采用新方法协调农药，水风险测试
3. U.S., Canada release draft workplan to further harmonize pesticide regulations [J] . Larry Pearl Pesticide & Chemical Policy . 2012,第8期

机译：美国，加拿大发布工作计划草案以进一步协调农药法规
4. Harmonized Approach to Future Toxicology Testing for Pesticide Regulation [C] . Kosei Inui International workshop on crop protection chemistry and regulatory harmonization . 2012

机译：农药监管未来毒理学检测的谐波方法
5. The economic rationale of harmonization of pesticide regulations between Canada and the United States [D] . Liang, Ming. 1994

机译：加拿大和美国之间统一农药法规的经济原理
6. The future of skin toxicology testing – Three-dimensional bioprinting meets microfluidics [O] . Wei Long Ng, Wai Yee Yeong 2019

机译：皮肤毒理学测试的未来–三维生物打印符合微流控技术
7. Harmonização e classificação toxicológica de agrotóxicos em 1992 no Brasil e a necessidade de prever os impactos da futura implantação do GHS Harmonization and toxicological classification of pesticides in 1992 in Brazil and the need to foresee the impacts from the forthcoming introduction of GHS [O] . Eduardo Garcia Garcia, Marco Antonio Bussacos, Frida Marina Fischer 2008

机译：巴西1992年农药的协调和毒理学分类以及预测GHS未来实施的影响的需要以及巴西1992年农药的协调性和毒理学分类的需求以及预见即将推出的GHS的影响
8. Pesticide Regulation (PR) Notice 96-8. Notice to Manufacturers, Formulators,Producers and Registrants of Pesticide Products. Toxicologically Significant Levels of Pesticide Active Ingredients [R] . 1996

机译：农药监管（pR）公告96-8。关于农药产品的制造商，配方设计师，生产商和注册者的通知。毒理学显着水平的农药有效成分

Harmonized Approach to Future Toxicology Testing for Pesticide Regulation

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