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首页> 外文会议>Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization >Studies on Metabolism and Disposition of Pesticides in Mammals by the Combined in vivo /vitro/silico Assessment Method
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Studies on Metabolism and Disposition of Pesticides in Mammals by the Combined in vivo /vitro/silico Assessment Method

机译：体内/体外/硅胶联合评估方法研究哺乳动物中农药的代谢和处置

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@@ In this study, an attempt is made to use a metabolism study as an accurate method to evaluate human risk by in vivo /vitro/silico combination assessment methods. They include the identification of small amounts of metabolites by nuclear magnetic resonance or mass spectrometry in addition to traditional in vivo metabolism study, in vitro metabolism study with cytochrome P450 (CYP) expressed in the microsome or tissue fraction, and in silico prediction of the characteristics of pesticides by physiologically-based pharmacokinetics (PBPK) modeling. The metabolism and characteristics of flufenpyr-ethyl, procymidone, furametpyr, and pyridalyl in animals were analyzed by these methods.
机译：在这项研究中，尝试通过体内/体外/硅胶联合评估方法将新陈代谢研究用作评估人类风险的准确方法。除了传统的体内代谢研究，使用微粒体或组织级分中表达的细胞色素P450（CYP）进行的体外代谢研究以及通过计算机模拟预测特征外，这些方法还包括通过核磁共振或质谱鉴定少量代谢物。基于生理学的药代动力学（PBPK）模型对农药进行分析用这些方法分析了氟苯吡咯乙酯，嘧啶酮，呋喃咪唑和哒嗪在动物体内的代谢和特征。

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