DEPENDANCE OF LINDENMAYER SYSTEM (L-SYSTEM) PARAMETERS ON FLOW CHARACTERISTICS IN ENGINEERED BIOMATERIALS

机译：LINDENMAYER系统参数（L-SYSTEM）对工程生物材料流动特性的依赖性

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Large thick tissue constructs have reported limited success primarily due to the inability of cells to survive deep within the scaffold. Without access to adequate nutrients, cells placed deep within the tissue construct will die out, leading to non-uniform tissue regeneration. In this research, we present several Lindenmayer system generated conduit networks in two and three-dimensional architecture with several degrees of complexity. The conduit network maintains a parent-child relationship between each branch of the network. Several L-system parameters have been studied - branching angle, branch length, ratio of parent to child branch diameter etc. We have developed a multi-physics based numerical model to predict the dependence of these L-system design parameters on the flow characteristics within the tissue construct. The implication of the simulation results will be discussed in terms of the design of 3D in-vitro tissue model systems.

机译：据报道，大型的厚组织构造物成功有限，这主要是由于细胞无法在支架内深处存活。如果无法获得足够的营养，放置在组织结构深处的细胞将死亡，导致组织再生不均匀。在这项研究中，我们以二维和三维体系结构介绍了几种Lindenmayer系统生成的管道网络，并具有一定程度的复杂性。管道网络在网络的每个分支之间维持父子关系。研究了多个L系统参数-分支角度，分支长度，母子分支直径之比等。我们开发了基于多物理场的数值模型来预测这些L系统设计参数对内部流动特性的依赖性。组织构造。将根据3D体外组织模型系统的设计来讨论仿真结果的含义。

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来源
《Proceedings of the ASME international mechanical engineering congress and exposition 2009》|2009年|P.1-5|共5页
会议地点 Lake Buena Vista FL(US);Lake Buena Vista FL(US)
作者
Ozlem Yasar; Shih Feng Lan; Binil Starly;
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作者单位

School of Industrial Engineering University of Oklahoma, Norman, OK 73019;

rnBioengineering Center University of Oklahoma, Norman, OK 73019;

rnSchool of Industrial Engineering University of Oklahoma, Norman, OK 73019;

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原文格式 PDF
正文语种 eng
中图分类机械设计、计算与制图;
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DEPENDANCE OF LINDENMAYER SYSTEM (L-SYSTEM) PARAMETERS ON FLOW CHARACTERISTICS IN ENGINEERED BIOMATERIALS

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