Aflatoxin and p53 gene mutation in hepatocellular carcinoma

机译：黄曲霉毒素和p53基因突变在肝细胞癌中

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There were reports from Qidong and southern Africa that the p53 gene of hepatocellular cercioma (HCC) had a mutational hot-sport at codon 249. Later there were repeated reports from Qidong. However, reports from world wide other than Qidong and southern africa witout this special mutational point occurred in HCC. It was supposed that 249 mutation could be casued by exposure t o aflatoxin Bl (AFB1) which was common environmental factor prevalent in Qidong and soutern Africa. Aspergillus flavus is distributed throughout the world. However, known for nature high AFBl contaminated areas are not common. Our aim is to study p53 gene mutational hot-sport in one more know nature high prevalent area Fusui and its neighbouring counties where HCC mortality rate is 40 out of one hundred thousand per year. AFB1 exposure and Hepatitis B virus (HBV) are both suspected as principal etiological factors.

机译：启东和南部非洲有报道称，肝细胞性宫颈癌（HCC）的p53基因在第249位密码子处发生了突变性热运动。后来，启东又多次报道。然而，除启东和南非以外，世界各地的报道均未发现这种特殊的突变点发生在肝癌中。据推测，暴露于黄曲霉毒素B1（AFB1）可能导致249个突变，而黄曲霉毒素B1（AFB1）在启东和非洲南部普遍存在。黄曲霉分布在世界各地。然而，自然界中已知AFB1高污染区并不常见。我们的目的是在一个已知的自然高度流行地区抚水及其附近的县中研究p53基因突变的热运动，这些县的HCC死亡率为每年十万分之40。 AFB1暴露和乙型肝炎病毒（HBV）均被怀疑是主要病因。

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《Proceedings of the Fourth China-Jpan international congress of mycology》|1998年|p.73-74|共2页
会议地点 Zhuhai(CN)
作者
Deng Zhuolin; Ma Yun;
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正文语种 eng
中图分类 Q9;
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1. An Investigation of Point Mutations at 7th Exon of Gene P53 in Hepatocellular Carcinoma Patients in Kermanshah Province and the Study of Mutation in Liver Specimens of Mice Exposed to Aflatoxin B1 [J] . M.H. Mirmomeni, S. Arveisi, S. Ghobadi, Research Journal of Biological Sciences . 2009,第1期

机译：克尔曼沙赫省肝细胞癌患者P53基因第7外显子的点突变调查及黄曲霉毒素B1暴露的小鼠肝脏标本突变研究
2. Hepatic aflatoxin B1-DNA adducts and TP53 mutations in patients with hepatocellular carcinoma despite low exposure to aflatoxin B1 in southern Japan. [J] . Shirabe K, Toshima T, Taketomi A, Liver international : . 2011,第9期

机译：尽管在日本南部很少接触黄曲霉毒素B1，但肝细胞癌患者的肝黄曲霉毒素B1-DNA加合物和TP53突变。
3. TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China. [J] . Szymanska K, Chen JG, Cui Y, Cancer epidemiology, biomarkers and prevention: A publication of the American Association for Cancer Research . 2009,第5期

机译：一组来自中国启东的慢性乙型肝炎病毒携带者中的TP53 R249S突变，黄曲霉毒素暴露和肝细胞癌的发生。
4. Aflatoxin and p53 gene mutation in hepatocellular carcinoma [C] . Deng Zhuolin, Ma Yun China-Jpan international congress of mycology . 1998

机译：肝细胞癌中的黄曲霉毒素和P53基因突变
5. The effect of aflatoxin on the HPRT gene, hepatitis B viral infection, and the subsequent development of hepatocellular carcinoma in the People's Republic of China. [D] . Wang, Sophia Sze-Yuan. 1998

机译：黄曲霉毒素对中国的HPRT基因，乙型肝炎病毒感染以及随后发生的肝细胞癌的影响。
6. Aflatoxin sufferer and p53 gene mutation in hepatocellular carcinoma [O] . Zhuo-Lin Deng, Yun Ma 1998

机译：肝细胞癌中的黄曲霉毒素患者和p53基因突变
7. Analysis of TP53 gene mutations demonstrates that aflatoxin is a risk factor for hepatocellular carcinoma in Guatemala [O] . Christian Alvarez Privado, Jeremy Ortiz, Giovanna Bendfeldt-Avila, 2019

机译：TP53基因突变分析表明，黄曲霉毒素是危地马拉肝细胞癌的危险因素

Aflatoxin and p53 gene mutation in hepatocellular carcinoma

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