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首页> 外文会议>Proceedings of Life in space for life on earth >EFFECTS OF 5-DAYS HEAD-DOWN BED-REST, WITH AND WITHOUT ARTIFICIAL GRAVITY COUNTERMEASURE, ON LEFT VENTRICULAR DIMENSIONS
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EFFECTS OF 5-DAYS HEAD-DOWN BED-REST, WITH AND WITHOUT ARTIFICIAL GRAVITY COUNTERMEASURE, ON LEFT VENTRICULAR DIMENSIONS

机译：有或没有人为重力对策的5天头枕向下对左心室尺寸的影响

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摘要

Our aims were: 1) to assess the effects of 5-days ofrnstrict head-down (-6 degrees) bed-rest (BR)rndeconditioning on left ventricular (LV) size and mass byrnechocardiography; 2) to test the effectiveness ofrnartificial gravity (AG) to prevent LV changes. Methods.rnTwelve healthy men (mean age 33±7) were enrolled in arncross-over design: each subject repeated the BRrn(MEDES, Toulouse) without countermeasures (CTRL),rnwith AG applied daily for 30’ continuously (AG1), andrnfor 30’ intermittently (AG2). Transthoracicrnechocardiography (iE33, Philips) was performed beforern(BCD-5), at the end of BR (R+0), and 3 days afterrn(R+2). Two-way ANOVA with repeated measures wasrnapplied. Results. Despite the smaller changes in AG1rnand AG2, no differences were found between groupsrnand interactions. Cardiac adaptation to deconditioningrnaffected LV mass and volumes, and AGrncountermeasure, when applied either continuously orrnintermittently, was not effective in preventing their loss.
机译：我们的目标是：1）通过超声心动图评估5天严格的头朝下（-6度）卧床休息（BR）脱位对左心室（LV）大小和质量的影响； 2）测试人造重力（AG）预防LV变化的有效性。方法：12名健康男性（平均年龄33±7）参加了交叉研究：每名受试者重复BRrn（MEDES，图卢兹）而没有采取对策（CTRL），每天连续应用AG连续30分钟（AG1），然后连续30次断断续续（AG2）。经胸腔超声心动图检查（iE33，Philips）在手术前（BCD-5），BR结束时（R + 0）和手术后3天（R + 2）进行。应用了重复测量的双向方差分析。结果。尽管AG1rn和AG2的变化较小，但组之间和相互作用之间没有发现差异。连续适应或间歇性应用对心脏适应失调影响的左室重量和容量，以及AGrn对策不能有效防止其丢失。

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  • 会议地点 Aberdeen(GB)
  • 作者

    Caiani EG; Massabuau P; Weinert L; Lairez O; Berry M; Va?da P; Lang RM;

  • 作者单位

    Politecnico di Milano, Biomedical Engineering Department, Piazza Leonardo da Vinci 32, 20133 Milano, Italy, Email: caiani@biomed.polimi.it;

    University Hospital of Rangueil, Department of Cardiology, 1 avenue du Pr Jean Poulhès, 31059 Toulouse Cedex, Toulouse, France, Email: massabuau.p@chu-toulouse.fr;

    University of Chicago, Noninvasive Cardiac Imaging Laboratory, 5841 S. Maryland Ave., M.C. 5084, Chicago, IL 60637, USA;

    University Hospital of Rangueil, Department of Cardiology, 1 avenue du Pr Jean Poulhès, 31059 Toulouse Cedex, Toulouse, France;

    University Hospital of Rangueil, Department of Cardiology, 1 avenue du Pr Jean Poulhès, 31059 Toulouse Cedex, Toulouse, France;

    Université Bordeaux Segalen, 146 rue Léo-Saignat, 33076 Bordeaux Cedex. Bordeaux, France,Email:pvaida@hotmail.com;

    University of Chicago, Noninvasive Cardiac Imaging Laboratory, 5841 S. Maryland Ave., M.C. 5084, Chicago, IL 60637, USA, Email: rlang@medicine.bsd.uchicago.edu;

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