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首页> 外文会议>Proceedings of Life in space for life on earth >COAGULATION CHANGES DURING GRADED ORTHOSTATIC STRESS AND RECOVERY
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COAGULATION CHANGES DURING GRADED ORTHOSTATIC STRESS AND RECOVERY

机译：矫正应力和恢复过程中的凝结变化

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Background: Orthostatic stress has been introduced asrna novel paradigm for activating the coagulation system.rnWe examined whether graded orthostatic stress (usingrnhead up tilt, HUT + lower body negative pressure,rnLBNP) until presyncope leads to anti / pro-coagulatoryrnchanges and how rapidly they return to baseline duringrnrecovery. Methodology: Eight male subjects werernenrolled in this study. Presyncopal runs were carried outrnusing HUT + LBNP. At minute zero, the tilt table wasrnbrought from 0° (supine) to 70 ° head-up position for 4rnmin, after which pressure in the LBNP chamber wasrnreduced to -15, -30, and -45 mm Hg every 4 min. Atrnpresyncope, the subjects were returned to supinernposition. Coagulatory responses and plasma massrndensity (for volume changes) were measured before,rnduring and 20 min after the orthostatic stress. Wholernblood coagulation was examined by means ofrnthrombelastometry. Platelet aggregation in whole bloodrnwas examined by using impedance aggregometry.rnThrombin generation parameters, prothrombin levels,rnand markers of endothelial activation were measured inrnplasma samples. Results: At presyncope, plasmarnvolume was 20 % below the initial supine value. Bloodrncell counts, prothrombin levels, thrombin peak,rnendogenous thrombin potential (ETP), and tissue factorrnpathway inhibitor (TFPI) levels increased during thernprotocol, commensurate with hemoconcentration. Thernmarkers of endothelial activation (tissue factor, TF,rntissue plasminogen activator, t-PA) and the markers ofrnthrombin generation (Prothrombin fragments 1 and 2,rnF1+2, and thrombin-antithrombin complex, TAT)rnincreased significantly. During recovery, all therncoagulation parameters returned to initial supine valuesrnexcept F1 +2 and TAT. Conclusion: Head-up tilt/LBNPrnleads to activation of the coagulation system. Some ofrnthe markers of thrombin formation are still at higherrnthan supine levels during recovery.
机译：背景：体位应激已被引入作为激活凝血系统的新范式.rn我们检查了分级的体位应激（使用抬头向上倾斜，HUT +下体负压，rnLBNP）直到晕厥前导致抗凝/促凝变以及它们恢复的速度如何恢复期间达到基准。方法：本研究招募了八名男性受试者。使用HUT + LBNP进行晕厥前奔跑。在零分钟处，将倾斜工作台从0°（仰卧）抬高至70°抬起位置持续4rnmin，此后，每4分钟将LBNP腔室中的压力降低至-15，-30和-45 mm Hg。在晕厥前，受试者被放回至上位。在直立应力之前，期间和之后20分钟，测量凝血反应和血浆质量密度（用于体积变化）。全血凝固通过血栓弹力测定法检查。采用阻抗聚集法检测全血中血小板的聚集情况。检测血浆样品中凝血酶的产生参数，凝血酶原水平，内皮细胞活化指标。结果：在晕厥前，血浆体积比初始仰卧位值低20％。在协议期间，血细胞计数，凝血酶原水平，凝血酶峰，内源性凝血酶潜能（ETP）和组织因子通路抑制物（TFPI）水平升高，与血药浓度相对应。内皮细胞活化标记物（组织因子，TF，组织纤溶酶原激活物，t-PA）和凝血酶生成标记物（凝血酶原片段1和2，rnF1 + 2和凝血酶-抗凝血酶复合物，TAT）显着增加。在恢复过程中，除F1 +2和TAT外，所有凝血参数均恢复到初始仰卧值。结论：抬头向上倾斜/ LBNPrn导致凝血系统激活。在恢复过程中，某些凝血酶形成的标志物仍高于仰卧位。

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