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首页> 外文会议>Proceedings of Life in space for life on earth >THE ESA IBER-3 PROJECT - GENE EXPRESSION AND CYTOKINE MONITORING FOR BIODOSIMETRY AND RADIATION SENSITIVITY SCREENING (GYMBRASS)
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THE ESA IBER-3 PROJECT - GENE EXPRESSION AND CYTOKINE MONITORING FOR BIODOSIMETRY AND RADIATION SENSITIVITY SCREENING (GYMBRASS)

机译：ESA IBER-3项目-用于生物剂量法和辐射敏感度筛查（陀螺）的基因表达和细胞因子监测

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摘要

In order to better understand and define the biologicalrnrisks of cosmic radiation, it is important to identifyrnbiomarkers for exposure and for predicting individualrnsensitivity to radiation-induced biological damage. Ourrnstudy aims at identifying new biomarkers for radiationrnexposure to low and high linear energy transfer (LET)rnradiation. We will focus on the use of gene, exon and/orrncytokine expression signatures in human peripheralrnblood mononuclear cells (PBMCs) as biomarkers. Theserndata will be integrated with those from DNA doublernstrand break (DSB) repair kinetics in order to identifyrnbiomarkers of individual radiosensitivity.rnOur preliminary data indicate that gene/exon expressionrnsignatures can be used to accurately predict radiationrndoses of below 0.1 Gy (X-rays). Additionally, specificrnexon signatures may further enhance the sensitivity ofrnprediction. Also, we found that there is a very strongrnoverlap between gene expression changes in response tornhigh doses (1 Gy) of low (X-ray) and high-LET (C-ions;rn50-75 keV/μm) irradiation. However, we also identifiedrngenes that only responded to either X-rays or C-ions,rnsuggesting that LET-specific gene signatures may alsornbe identified.
机译：为了更好地理解和定义宇宙辐射的生物学风险，重要的是确定暴露的生物标志物并预测个体对辐射诱发的生物损伤的敏感性。我们的研究旨在确定用于低线和高线能量转移（LET）辐射的新生物标记。我们将重点关注人类外周血单核细胞（PBMC）中基因，外显子和/或核糖体细胞因子表达特征的使用作为生物标记。这些数据将与DNA双链断裂（DSB）修复动力学的数据整合在一起，以鉴定单个放射敏感性的生物标志物。我们的初步数据表明，基因/外显子表达特征可用于准确预测低于0.1 Gy的放射剂量（X射线）。另外，特定的勒克森标记可以进一步增强预测的敏感性。同样，我们发现响应高剂量（1 Gy）的低剂量（X射线）和高LET（C离子； rn50-75 keV /μm）辐射，基因表达变化之间存在非常强的重叠。但是，我们还鉴定了仅对X射线或C离子有反应的基因，暗示也可能鉴定出LET特异的基因签名。

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  • 会议地点 Aberdeen(GB)
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    Roel Quintens; Marjan Moreels; Kevin Tabury; Ellina Macaeva; Arlette Michaux; Nicole Averbeck; Alexander Choukèr; Sarah Baatout;

  • 作者单位

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium. E-mail:roel.quintens@sckcen.be;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium;

    Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany;

    Department of Anaesthesiology, Ludwig-Maximillians University, Munich, Germany;

    Radiobiology Unit, SCK?CEN, Boeretang 200, 2400 Mol, Belgium Dept Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Gent, Belgium;

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