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首页> 外文会议>Proceedings of the world medical conference >Medically induced abortion in second trimester with intravaginal misoprostol
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Medically induced abortion in second trimester with intravaginal misoprostol

机译：妊娠中期阴道内米索前列醇的药物流产

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Prostaglandins are more and more used for second trimester pregnancy termination. Their preferential application is vaginal and because the intracervical variant is laborious and invasive, the posterior vaginal fornix became increasingly used and investigated. Misoprostol is an E_1 prostaglandin synthetic analog with an innocuity equivalent to that of E_2 prostaglandin, but doubled by an increased efficiency and a lower cost. This study is intended to extend the existent experience regarding the intravaginal misoprostol for second trimester therapeutic abortion induction. This prospective clinic study selected 20 pregnant women, with a gestational age of 15 to 27 weeks who have been checked in the Clinic of Obstetrics-Gynecology of the University of Medicine and Pharmacy of Craiova, for therapeutic abortion induction. The 20 pregnant women received in PVF a 200μg misoprostol tablet each 12 hours, respecting strictly the protocol developed by the authors. Our results demonstrate clearly that in the conditions of therapeutic correction/counteraction of the complications associated to pregnancies that must be terminated in the second trimester, the rate of abortion in the first 24 hours from the intravaginal misoprostol application (following the protocol developed by the authors) can become 100%, while the average duration of the abortion induced in the same manner drops to under 12 hours. Our observations indicate a rate of complete abortion of 60%, which reduced significantly the rate of postabortum curettage, in the same time opening new perspectives to fetal transplantation and noninvasive investigation of the amniotic fluid. So, the misoprostol applied in the posterior vaginal fornix following the protocol elaborated by us is a physiological, practical and effective method if it adapts to the particularities of the case as dose and timely associated therapy.
机译：前列腺素越来越多地用于终止中期妊娠。它们的优选用途是阴道，并且由于神经内变体费力且具有侵入性，因此阴道后穹ni越来越多地被使用和研究。米索前列醇是E_1前列腺素的合成类似物，其无毒度与E_2前列腺素相当，但通过提高效率和降低成本而倍增。这项研究旨在扩大有关阴道内米索前列醇用于妊娠中期治疗性流产的现有经验。这项前瞻性临床研究选择了20名怀孕年龄在15至27周的孕妇，这些孕妇在克拉约瓦医药大学的妇产科诊所接受了检查，以进行治疗性流产。 20名孕妇每12小时在PVF中接受200μg米索前列醇片剂，严格遵守作者制定的方案。我们的结果清楚地表明，在必须在孕中期终止与妊娠相关的并发症的治疗性矫正/抵消性条件下，应用米索前列醇阴道内应用米索前列醇的最初24小时内的流产率（遵循作者制定的方案） ）可以达到100％，而以相同方式诱发的流产的平均持续时间降至12小时以下。我们的观察结果表明完全流产的比率为60％，这大大降低了产后刮宫的比率，同时为胎儿移植和羊水的非侵入性研究开辟了新的前景。因此，按照我们制定的方案，将米索前列醇应用于阴道后穹if是一种生理，实用和有效的方法，前提是它可以根据具体情况进行剂量和及时的相关治疗。

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