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Opportunities of QPI in the epigenetic diagnostics and assessment of therapeutic efficacy

机译：QPI在表观遗传学诊断和治疗效果评估中的机会

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摘要

Quantitative phase imaging (QPI) can be considered as a potential tool to extract important information on the refractive index of the cellular and subcellular structures. Interphase chromatin is an original biosensor, a detector of early changes in morphofunctional cell condition. The authors presented a technology of densitometric segmentation based on the quantitative phase microscopy and computed analysis of the changes in the optic density of interphase chromatin as a biosensor. The purpose of this work to evaluate the possibility of quantitative phase imaging for visualizing the nuclear proteins conformation and chromatin decondensation degree. Modification of chromatin structure, compactness of its package, and so on, are indicative of cell condition alteration and may be projected on the organism as a whole not only for the early preclinical diagnostics but also for assessment of prognosis in crisis conditions.
机译：定量相位成像（QPI）可被认为是提取有关细胞和亚细胞结构折射率的重要信息的潜在工具。相间染色质是一种原始的生物传感器，是形态功能细胞状况早期变化的检测器。作者提出了一种基于定量相显微镜的光密度分割技术，并对作为生物传感器的相间染色质的光密度变化进行了计算分析。这项工作的目的是评估定量相成像以可视化核蛋白构象和染色质去缩度的可能性。染色质结构的改变，其包装的紧密性等都表明细胞状况发生了变化，不仅可以用于早期临床前诊断，而且可以用于评估危机条件下的预后，从而可以预测整个生物体。

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  • 来源
    《Quantitative phase imaging III》|2017年|1007417.1-1007417.5|共5页
  • 会议地点 San Francisco(US)
  • 作者

    Irina Vasilenko; Vladislav Metelin; Aleksandr Kuznetsov; Vladimir Belyakov; Tatiana Yakushina;

  • 作者单位

    Maimonides Academy, 52/45 Sadovnicheskaya str., Moscow, Russian Federation 115035,M.F.Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI), 61/2, Schepkina str., Moscow, Russian Federation 129110;

    Maimonides Academy, 52/45 Sadovnicheskaya str., Moscow, Russian Federation 115035,M.F.Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI), 61/2, Schepkina str., Moscow, Russian Federation 129110;

    N.I. Pirogov Russian National Research Medical University, 1, Ostrovityanova str., Moscow, Russian Federation 117997;

    N.I. Pirogov Russian National Research Medical University, 1, Ostrovityanova str., Moscow, Russian Federation 117997;

    M.F.Vladimirsky Moscow Regional Clinical and Research Institute (MONIKI), 61/2, Schepkina str., Moscow, Russian Federation 129110;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    interference microscopy; phase thickness; interphase chromatin; chromosome territories; multiple sclerosis; densimetric nuclear segmentation;

    机译：干涉显微镜相厚间期染色质染色体区域多发性硬化症;密度核分割;

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