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Surface anticoagulation modification of TiNi alloy by albumin-immobilization

机译：固定白蛋白对TiNi合金的表面抗凝改性

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The use of TiNi class of Shape Memory Effect (SME) alloys in the biomedical field has become a well established area be cause TiNi fulfills the property requirements better than any competing material.Especially the property of excellent free recovery,where it is beneficial for stents.In order to improve the biological safety and haemocompatibility of matrix material,a layer of TiO2 film was pre pared by sol-gel method on the surface of TiNi alloy. Then,the NH2-active group was introduced on the surface of coated samples through treatment in amination solution.Finally,the albumin was linked on the surface of TiO_2 film through the NH2- active group and layer-by-layer technology. The surface characteristics of the samples were successively performed and tested by XRD,SEM and EDS. The in vitro blood compatibility of the TiNi alloy with and without albumin-immobilization were evaluated by clotting time measurement and platelet adhesion test,and the results showed that the anticoagulation and haemocompatibility of the TiNi alloy could be remarkably improved by surface modification via albumin-immobilization.
机译：TiNi类形状记忆效应（SME）合金在生物医学领域的应用已成为公认的领域，因为TiNi可以比任何竞争材料都更好地满足性能要求。特别是出色的自由恢复性能，这对支架有益为了提高基体材料的生物安全性和血液相容性，采用溶胶-凝胶法在TiNi合金表面制备了一层TiO2薄膜。然后，通过胺化溶液处理，将NH2-活性基团引入涂层样品的表面。最后，通过NH2-活性基团和逐层技术将白蛋白连接在TiO_2薄膜的表面上。样品的表面特性依次进行了XRD，SEM和EDS测试。通过凝结时间测量和血小板粘附试验评估了固定和不固定白蛋白的TiNi合金的体外血液相容性，结果表明，通过固定白蛋白的表面改性可以显着改善TiNi合金的抗凝性和血液相容性。 。

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