Single-cell imaging detection of nanobarcoded nanoparticle biodistributions in tissues for nanomedicine

机译：单细胞成像检测纳米条形码在组织中的纳米条形码生物分布。

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In nanomedicine, biodistribution studies are critical to evaluate the safety and efficacy of nanoparticles. Currently, extensive biodistribution studies are hampered by the limitations of bulk tissue and single-cell imaging techniques. To ameliorate these limitations, we have developed a novel method for single nanoparticle detection that incorporates a conjugated oligonucleotide as a "nanobarcode" for detection via in situ PCR. This strategy magnifies the detection signal from single nanoparticles, facilitating rapid evaluation of nanoparticle uptake by cell type over larger areas. The nanobarcoding method can enable precise analysis of nanoparticle biodistributions and expedite translation of these nanoparticles to the clinic.

机译：在纳米医学中，生物分布研究对于评估纳米颗粒的安全性和有效性至关重要。目前，大量的生物分布研究受到大块组织和单细胞成像技术的限制。为了改善这些局限性，我们开发了一种用于单纳米颗粒检测的新方法，该方法将结合的寡核苷酸作为“纳米条形码”并通过原位PCR进行检测。该策略可放大单个纳米颗粒的检测信号，从而有助于按细胞类型对较大面积的纳米颗粒摄取进行快速评估。纳米条形码方法可以精确分析纳米颗粒的生物分布，并加快将这些纳米颗粒翻译到临床的速度。

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《Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications III》|2011年|p.79100O.1-79100O.11|共11页
会议地点 San Francisco CA(US)
作者
Trisha Eustaquio; Christy L. Cooper; James F. Leary;
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作者单位

Weldon School of Biomedical Engineering;

Department of Basic Medical Sciences-School of Veterinary Medicine;

Weldon School of Biomedical Engineering,Department of Basic Medical Sciences-School of Veterinary Medicine,Bindley Bioscience Center,Birck Nanotechnology Center,Purdue University, West Lafayette, Indiana;

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正文语种 eng
中图分类医用物理学;
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1. Nanobarcoded Superparamagnetic Iron Oxide Nanoparticles for Nanomedicine: Quantitative Studies of Cell-Nanoparticle Interactions by Scanning Image Cytometry [J] . Eustaquio Trisha, Leary James F. Cytometry, Part A: the journal of the International Society for Analytical Cytology . 2016,第2期

机译：纳米条形码的超顺磁性氧化铁纳米粒子用于纳米医学：通过扫描图像细胞术对细胞-纳米粒子相互作用的定量研究。
2. Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy [J] . Tianyuzi Li, Howard E Gendelman, Gang Zhang, International Journal of Nanomedicine . 2015,第Supplementa1期

机译：叶酸包覆磁铁矿纳米粒子的磁共振成像反映了长效抗逆转录病毒疗法的组织生物分布
3. Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy [J] . Tianyuzi Li, Howard E Gendelman, Gang Zhang, International Journal of Nanomedicine . 2015,第Supplementa1期

机译：叶酸包覆磁铁矿纳米粒子的磁共振成像反映了长效抗逆转录病毒疗法的组织生物分布
4. Single-cell imaging detection of nanobarcoded nanoparticlebiodistributions in tissues for nanomedicine [C] . Trisha Eustaquio, Chris L. Cooper, James F. Leary SPIE Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications . 2011

机译：纳米医生组织中纳米型纳米粒子二十碱基碱基的单细胞成像检测
5. Analysis of an optical coherence imaging modality on the detection of an abnormality in biological tissue with a nanoparticle contrast agent. [D] . Cheong, Kit-Iu. 2007

机译：用纳米粒子造影剂检测生物组织中的异常的光学相干成像方式进行分析。
6. Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy [O] . Tianyuzi Li, Howard E Gendelman, Gang Zhang, 2015

机译：叶酸包覆磁铁矿纳米粒子的磁共振成像反映了长效抗逆转录病毒疗法的组织生物分布
7. Nanobarcoded superparamagnetic iron oxide nanoparticles for nanomedicine: Quantitative studies of cell-nanoparticle interactions by scanning image cytometry [O] . Trisha Eustaquio, James F. Leary 2015

机译：用于纳米胺的纳米式超顺磁性氧化铁纳米粒子：通过扫描图像细胞术分析细胞纳米粒子相互作用的定量研究

Single-cell imaging detection of nanobarcoded nanoparticle biodistributions in tissues for nanomedicine

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