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Plant Virus-Resembling Optical Nano-materials Conjugated with Anti-EGFR for Targeted Cancer Imaging

机译:结合抗EGFR的植物病毒重组光学纳米材料用于靶向癌症成像

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We recently reported the construction of a new type of optically active nano-particles composed of genome-depleted plant infecting brome mosaic virus (BMV) doped with indocyanine green (ICG), an FDA-approved chromophore . We refer to these constructs as optical viral ghosts (OVGs) since only the capsid protein (CP) subunits of BMV remain to encapsulate ICG. Herein, we covalently conjugated the surface of OVGs with anti-epidermal growth factor receptors (anti-EGFR) to target cancerous human bronchial epithelial cells (C-HBECs) in-vitro. Our preliminary results demonstrate the utility of conjugated OVGs for targeted imaging of cancer cells.
机译:我们最近报道了一种新型的光学活性纳米粒子的构建,该纳米粒子由缺失基因组的植物感染掺有吲哚菁绿(ICG)(一种FDA批准的生色团)的溴化花叶病毒(BMV)组成。由于仅BMV的衣壳蛋白(CP)亚基保留来封装ICG,因此我们将这些构建体称为光学病毒重影(OVG)。在本文中,我们将OVG表面与抗表皮生长因子受体(anti-EGFR)共价缀合,以体外靶向癌性人支气管上皮细胞(C-HBECs)。我们的初步结果证明了缀合的OVG可以用于癌细胞的靶向成像。

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