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Cancer Therapy Utilizing Molecular Layer Deposition (MLD) and Self-Organized Lightwave Network (SOLNET): Proposal and Theoretical Prediction

机译:利用分子层沉积(MLD)和自组织光波网络(SOLNET)的癌症治疗:建议和理论预测

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Cancer therapy utilizing Molecular Layer Deposition (MLD) and Self-Organized Lightwave Network (SOLNET) is proposed. MLD is a growth method, in which different kinds of molecules are sequentially provided to a substrate to synthesize organic tailored materials with designated molecular arrangements. In cancer therapy, the liquid-phase MLD (LP-MLD) is used with regarding the human body as the MLD chamber and the cancer cells as the substrates. The first proposal is the selective delivery of multi-functional materials with imaging, sensitizing, paramagnetic, light-absorbing agents etc. to cancer cells by LP-MLD. The second proposal is in-situ synthesis of drugs, especially large and toxic ones, at cancer cells by LP-MLD to deliver the drugs deep inside the cancer without attacking normal cells. The third proposal is the SOLNET-assisted laser surgery. After luminescent molecules are adsorbed in cancer cells by LP-MLD, a write beam is introduced from an optical fiber into the area containing cancer cells through photo-induced refractive index increase materials to construct self-aligned optical waveguides of SOLNET, which selectively guides surgery beams to cancer cells. Theoretical predictions and preliminary experimental results are presented.
机译:提出了利用分子层沉积(MLD)和自组织光波网络(SOLNET)的癌症治疗方法。 MLD是一种生长方法,其中将不同种类的分子顺序提供给基板,以合成具有指定分子排列的有机定制材料。在癌症治疗中,液相MLD(LP-MLD)用于将人体作为MLD腔室,而将癌细胞作为基质。第一个建议是通过LP-MLD将具有成像,敏化,顺磁性,光吸收剂等功能的多功能材料选择性地递送至癌细胞。第二个建议是通过LP-MLD在癌细胞上原位合成药物,特别是大而有毒的药物,以将药物输送到癌症深处而不会攻击正常细胞。第三个建议是SOLNET辅助的激光手术。 LP-MLD将发光分子吸附在癌细胞中后,通过光诱导的折射率增加材料将写入光束从光纤引入包含癌细胞的区域,以构建SOLNET的自对准光波导,从而有选择地指导手术射向癌细胞。给出了理论预测和初步实验结果。

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