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Fluorescence characterization of water-driven self-assembled lipids and their temperature-induced phase transitions

机译：水驱动自组装脂质的荧光表征及其温度诱导的相变

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Water-driven self-assembly of lipids displays a variety of liquid crystalline phases that are crucial for membrane functions. In this work, we characterized the temperature-induced phase transitions in aqueous self-assembly systems using steady-state and time-resolved fluorescence measurements. The polar head group region was investigated using tryptophan (Trp) and two of its ester derivatives, and the hydrophobic tail region was probed using pyrene. The spectral changes in tryptophan and pyrene were used as a benchmark to estimate the polarity of the head group region and the tail region, respectively. A basic medium was detected and estimated for the polar region in the inverse cubic phase of a Guerbet glycolipid and was attributed to the structural effect of the narrow nanochannels. All the studied lipid compositions show completely reversible temperature-induced phase transitions, reflecting the thermodynamic equilibrium structures of their mesophases. The results reveal a large degree of heterogeneity and flexibility of the lipid self-assembly which may be crucial for carrying out different biological functions.
机译：由水驱动的脂质自组装显示出各种液晶相，这对于膜功能至关重要。在这项工作中，我们使用稳态和时间分辨荧光测量来表征水性自组装系统中温度诱导的相变。使用色氨酸（Trp）及其两个酯衍生物研究极性头基区域，并使用pyr探测疏水性尾部区域。色氨酸和pyr的光谱变化被用作基准来分别估计头组区域和尾部区域的极性。检测并估计了一种Guerbet糖脂反相立方相中极性区域的基本介质，这归因于窄纳米通道的结构效应。所有研究的脂质成分均显示出完全可逆的温度诱导相变，反映了其中间相的热力学平衡结构。结果显示脂质自组装的高度异质性和灵活性，这对于执行不同的生物学功能可能至关重要。

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