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PM Titanium - Based Composites with Improved Biocompatibility

机译：具有改善的生物相容性的PM钛基复合材料

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摘要

Although titanium is considered to be the most successful metal for uncemented endosseous implants, its biocompatibility may be unsatisfactory in certain clinical cases. As an early osseointegration is essential in order to reduce the implant failure risk, the bioactive fixation becomes the appropriate solution for bone applications. The method requires bioactive materials such as hydroxyapatite (HA) to facilitate the chemical bonding to tissue. The present work refers to Ti-HA composites designed for endosseous implants and obtained through the classic PM route. Grade 1 c.p. Ti powder obtained through the hydriding - milling - dehydriding process, 63 - 100 μm grain size, was used. Sol-gel HA powder, grain size of less than 100 urn, was obtained through the sol-gel method. Blends of Ti and 5 to 50% HA were compacted in a rigid die (0.5 cm~2), without the use of any lubricant, with 400, 500 and 600 MPa, then vacuum sintered (106 torr) at 1160℃ for 60 minutes. Samples are well sintered with a compactness that increases with the applied compaction pressure. A transition layer can be seen in the EDX at the interface between the Ti matrix and the HA particles and is expected to increase the overall mechanical stability of compacts. The pores, essential for osseointegration, are interconnected, with irregular shapes and sizes that reach 100 μm, the critical size needed for the formation of a vital new bone. The HA content has to be limited to 30%, not to lead to an excessive brittleness. The biologic viability of compacts was assessed by immersion for 7 days into a simulated body fluid (SBF). The subsequent XRD analyses have proven that a new HA layer is formed on the surface of samples. This layer is essential for accelerating the cellular response of osteoblasts in the body.
机译：尽管钛被认为是非骨水泥植入物最成功的金属，但在某些临床情况下其生物相容性可能并不令人满意。由于早期骨整合对于降低植入物失败的风险至关重要，因此生物活性固定成为骨应用的合适解决方案。该方法需要生物活性材料，例如羟基磷灰石（HA），以促进化学键合到组织上。目前的工作涉及为骨内植入物设计的Ti-HA复合材料，并通过经典的PM途径获得。 1年级使用通过氢化-研磨-脱水过程获得的钛粉，粒度为63-100μm。通过溶胶-凝胶法获得粒度小于100微米的溶胶-凝胶HA粉末。将Ti和5至50％HA的混合物在400、500和600 MPa的刚性模具中（0.5 cm〜2）压实，不使用任何润滑剂，然后在1160℃真空烧结（106托）60分钟。样品烧结良好，压实度随施加的压实压力而增加。可以在EDX中看到Ti基体与HA颗粒之间界面的过渡层，该过渡层有望增加压坯的整体机械稳定性。骨整合必不可少的孔相互连通，其不规则形状和尺寸达到100μm，这是形成重要的新骨所需的关键尺寸。 HA含量必须限制在30％，以免导致过脆。通过将其浸入模拟体液（SBF）中7天来评估压块的生物活性。后续的XRD分析已证明在样品表面上形成了新的HA层。该层对于加速体内成骨细胞的细胞反应至关重要。

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  • 来源
    《Researches in Powder Metallurgy》|2009年|p.303-306|共4页
  • 会议地点 Craiova(RO);Craiova(RO)
  • 作者

    Catalin Popa; Viorica Simon; Gabriel Batin; Codruta Pavel; lonut Gligor; Liana Cont; Viorel Candea;

  • 作者单位

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

    "Babes-Bolyai" University of Cluj-Napoca, Department of Biomedical Physics,1, M.Kogalniceanu Str., 400084 Cluj-Napoca, Romania;

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

    Technical University of Cluj-Napoca, Department of Materials Science and Technology,103-105, Muncii Ave., 400641 Cluj-Napoca, Romania;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 粉末冶金（金属陶瓷工艺）;
  • 关键词

    titanium - hydroxyapatite composites; biocompatibility; simulated body fluid;

    机译：钛-羟基磷灰石复合材料;生物相容性模拟体液;

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