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首页> 外文会议>The Second Asian symposium on pharmaceutical sciences and technology >Viscometric behavior of hydrophobically modified HPMC (SANGELOSE(R)) under mechanical shearing and its application to topical products
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Viscometric behavior of hydrophobically modified HPMC (SANGELOSE(R)) under mechanical shearing and its application to topical products

机译：疏水改性的HPMC（SANGELOSE（R））在机械剪切下的粘度行为及其在局部产品中的应用

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Purpose: The clarification of viscosity characteristics of aqueous polymer gel under mechanical shearing is important for formulation design of gel and emulsion dosage forms in cosmetic and pharmaceutical field. This study was focused on the clarification of viscosity change of aqueous SGL gel by an agitating homogenizer and a microfluidizer. Methods: Homogenizer as a medium mechanical shearing machine and microfluidizer as an extremely mechanical high shearing one were used, respectively. The viscosity of SGL gel was investigated by treating with respective shearing, that is revolution speed/operation time in homogenizer's case and operation pressure/passing time in case of microfluidizer's one. Carboxyvinylpolymer was used for comparison. Results: It was found that the viscosity of SGL gel was stable under medium mechanical shearing by a homogenizer. Viscosities under extremely high shearing by a microfluidizer were decreased; however the decrease level of viscosity might be tolerable to prepare nano-emulsion dosage form. On the other hand, CVP gel is unstable in viscosity under medium and high shearing.
机译：目的：澄清水性聚合物凝胶在机械剪切下的粘度特性对于化妆品和制药领域的凝胶和乳液剂型的配方设计很重要。这项研究的重点是通过搅拌均质器和微流化器澄清SGL水性凝胶的粘度变化。方法：分别使用均质机和中流微机作为中度机械剪切机。 SGL凝胶的粘度通过分别进行剪切来研究，即在均质器的情况下为转速/操作时间，在微流化器的情况下为操作压力/通过时间。羧基乙烯基聚合物用于比较。结果：发现在均质机的中等机械剪切下，SGL凝胶的粘度是稳定的。微流化器在极高剪切下的粘度降低；然而，制备纳米乳剂型可以降低粘度的水平。另一方面，CVP凝胶在中等和高剪切下的粘度不稳定。

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