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Evaluation of pharmaceutical powder flowability by a new shear-cell test method

机译：通过新的剪切池测试方法评估药物粉末的流动性

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Purpose: Shear-cell test method has been used extensively as one of the important methods to evaluate the flowability of pharmaceutical powders. Many different shear tests have been developed, though they are variations on the same theme of Jenike shear test experimental principle and the equipment and methodology used are complex and varied. The purse of the study is to develop a new shear test method and generally accepted standards for evaluation of pharmaceutical powders flowability.; Method: Based on constant volume single shear test principle, one-step method without precompression and pre-shear test, was developed for the determination of normal stress and shear stress of powders with different porosity. Failure envelope was obtained through the analysis of various mechanical parameters of powders and compared with the Jenike method results.; Results: A series of experimental parameters, such as envelope equation and internal friction angle, were obtained by the new shear test method with simple steps and short time, which were found to have good correlation with Jenike experiment results. The new method was also proved to have high precision and good reproducibility. Conclusion: The new shear test method provides a theoretical foundation for comprehensive and accurate evaluation and prediction of flowability of pharmaceutical powders.
机译：目的：剪切细胞测试法已被广泛用作评估药物粉末流动性的重要方法之一。已经开发了许多不同的剪切测试，尽管它们是对Jenike剪切测试实验原理的同一主题的变体，并且所使用的设备和方法复杂而多样。研究的目的是开发一种新的剪切试验方法和公认的标准，以评估药物粉末的流动性。方法：基于恒容单剪切试验原理，开发了一种无需预压缩和预剪切试验的一步法，用于测定不同孔隙度的粉末的正应力和剪切应力。通过分析粉末的各种机械参数获得破坏包络，并将其与詹尼克方法的结果进行比较。结果：采用新的剪切试验方法，以简便的步骤，较短的时间，获得了包络方程和内摩擦角等一系列实验参数，与Jenike实验结果具有良好的相关性。新方法还被证明具有高精度和良好的重现性。结论：新的剪切试验方法为全面，准确地评估和预测药物粉末的流动性提供了理论基础。

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