• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Second joint biostatistics symposium (2012) >Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus,Acellular Pertussis, Inactivated Poliovirus,and Haemophilus Influenzae Type b
【24h】

Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus,Acellular Pertussis, Inactivated Poliovirus,and Haemophilus Influenzae Type b

机译：接种白喉，破伤风，无细胞百日咳，脊髓灰质炎灭活病毒和b型流感嗜血杆菌疫苗后出现高热惊厥和癫痫的风险

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

STUDIES HAVE REPORTED IN-creased risks of febrile seizures shortly after administration ofwhole-cell pertussis vaccine,1.2 as would be expected since the whole-cell pertussis vaccine often causes fever.Whole-cell pertussis vaccine has also been associated with serious neurological illnesses characterized by seizures and intellectual impairment,3'4 but recent studies indicate that the vaccination only triggers an earlier onset of severe epileptic encephalopathy in children with sodium channel gene mutations.5-7 The cellular pertussis vaccine has replaced the whole-cell pertussis vaccine in most countries because the efficacy of the acellular vaccine is comparable with the whole-cell vaccine and it has substantially fewer adverse effects, including fever.8-12 Previous randomized controlled trials did not reveal differences in the risk of seizures after acellular pertussis vaccination compared with whole-cell pertussis vaccination, but the trials were not powered to detect rare adverse effects.
机译：研究报告称，在接种全细胞百日咳疫苗后不久，高热惊厥的风险增加，这是预期的，因为全细胞百日咳疫苗通常会引起发烧。全细胞百日咳疫苗还与严重的神经系统疾病有关，其特征是癫痫发作和智力障碍，3'4，但最近的研究表明，该疫苗接种仅会触发具有钠通道基因突变的儿童发生严重癫痫性脑病。5-7在大多数国家，细胞百日咳疫苗已替代了全细胞百日咳疫苗因为无细胞疫苗的功效与全细胞疫苗相当，并且副作用少得多，包括发烧。8-12先前的随机对照试验并未显示与全细胞疫苗相比，无细胞百日咳疫苗接种后癫痫发作风险的差异。细胞百日咳疫苗接种，但试验无能力检测罕见的不良反应的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号