• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Sensing for Agriculture and Food Quality and Safety VII >Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids
【24h】

Nature-inspired magnetoelastic biosentinels for the detection of pathogenic bacteria in stagnant liquids

机译：受自然启发的磁弹性生物前哨，用于检测停滞液体中的病原细菌

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This paper presents an investigation into magnetoelastic (ME) biosentinels that capture and detect low-concentration pathogenic bacteria in stagnant liquids. The ME biosentinels are designed to mimic a variety of white blood cell types, known as the main defensive mechanism in the human body against different pathogenic invaders. The ME biosentinels are composed of a freestanding ME resonator coated with an engineered phage that specifically binds with the pathogens of interest. These biosentinels are ferromagnetic and thus can be moved through a liquid by externally applied magnetic fields. In addition, when a time-varying magnetic field is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. As soon as the biosentinels bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel's resonant frequency occurs, and thereby the presence of the target pathogen can be detected. Detection of Bacillus anthracis spores under stagnant flow conditions was demonstrated.
机译：本文提出了对磁弹性（ME）生物哨兵的研究，该磁哨兵可以捕获和检测滞留液体中的低浓度致病细菌。 ME生物前哨旨在模拟多种白细胞类型，被称为人体针对不同病原体入侵者的主要防御机制。 ME生物探针由独立的ME共振器组成，该共振器上涂有工程噬菌体，可与目标病原体特异性结合。这些生物前哨是铁磁性的，因此可以通过外部施加的磁场在液体中移动。另外，当施加时变磁场时，可以通过磁致伸缩将ME生物前哨置于机械共振中。一旦生物哨兵通过基于噬菌体的生物分子识别与靶标病原体结合，生物哨兵的共振频率就会发生变化，从而可以检测到靶标病原体的存在。证明了在停滞流动条件下检测炭疽芽孢杆菌孢子。

著录项

  • 来源
  • 会议地点 Baltimore MD(US)
  • 作者

    Shin Horikawa; Yating Chai; Howard C. Wikle; Jing Dai; Jiajia Hu; Sang-Jin Suh; Vitaly Vodyanoy; Bryan A. Chin;

  • 作者单位

    Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;

    Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;

    Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;

    Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;

    Jiangsu Key Laboratory of Materials Surface Technology, School of Materials Science and Engineering, Changzhou University, Jiangsu 213164, China;

    Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA;

    Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, USA;

    Materials Research and Education Center, Auburn University, Auburn, AL 36849, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Magnetoelastic; biosentinel; phage; detection; pathogen; Bacillus anthracis;

    机译：磁弹性生物前哨噬菌体检测;病原;炭疽芽孢杆菌;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号