A biosensor based on magnetic resonance relaxation

机译：基于磁共振弛豫的生物传感器

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

This work describes a biosensor based on magnetic resonance relaxation switching. The method leverages a large body of work involving nanoscale contrast agents employed in nuclear magnetic resonance (NMR) imaging. The aim was to develop a detection approach that mimics the human immune response to an invading pathogen, the release of 10~9 to 10~(12) specific antigens to guarantee quick contact with the pathogen. The technique employs magnetic nanoparticle contrast agents conjugated with specific capture agents to achieve a similar contact goal. Detection of the species involves monitoring the average relaxation time (T2) of water protons in the solution, which is highly sensitive to the concentration and distribution of the magnetic nanoparticles present. With multiple nanoparticles attaching to each individual target species their distribution will be altered, and correspondingly, the average proton relaxation time will change.

机译：这项工作描述了基于磁共振弛豫切换的生物传感器。该方法利用了涉及核磁共振（NMR）成像的纳米级造影剂的大量工作。目的是开发一种检测方法，以模仿人类对入侵病原体的免疫反应，释放10〜9至10〜（12）种特异性抗原，以确保与病原体的快速接触。该技术采用与特定捕获剂结合的磁性纳米粒子造影剂，以实现类似的接触目标。物质的检测涉及监测溶液中水质子的平均弛豫时间（T2），该时间对存在的磁性纳米粒子的浓度和分布高度敏感。通过将多个纳米粒子附着到每个单独的目标物种上，它们的分布将发生变化，相应地，平均质子弛豫时间也将发生变化。

著录项

来源
《Sensing for Agriculture and Food Quality and Safety VII》|2015年|94880B.1-94880B.6|共6页
会议地点 Baltimore MD(US)
作者
M. Sullivan; B.C. Prorok;
展开▼
作者单位

Department of Mechanical Engineering, Auburn University, Auburn, Alabama 36849, USA;

Department of Mechanical Engineering, Auburn University, Auburn, Alabama 36849, USA;

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类
关键词
biosensor; detection; NMR; food safety;

机译：生物传感器检测; NMR;食品安全;

相似文献

外文文献
中文文献
专利

1. Detection limits for ferrimagnetic particle concentrations using magnetic resonance imaging based proton transverse relaxation rate measurements. [J] . Pardoe H, Chua anusorn W, St Pierre TG, Physics in medicine and biology. . 2003,第6期

机译：使用基于磁共振成像的质子横向弛豫率测量来测量亚铁磁颗粒浓度的检测限。
2. PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood [J] . Dong Yun Lee, Sukmo Kang, Yonghyun Lee, Theranostics . 2020,第5期

机译：聚乙二醇胆红素涂层的氧化铁纳米粒子作为磁性松弛切换的磁化传感器的生物传感器，全血
3. Magnetic resonance relaxation induced by superparamagnetic particles used as contrast agents in magnetic resonance imaging: a theoretical review [J] . Vuong Quoc Lam, Gillis Pierre, Roch Alain, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology . 2017,第6期

机译：由超顺磁性颗粒诱导的磁共振弛豫用作磁共振成像中的造影剂：一个理论综述
4. A biosensor based on magnetic resonance relaxation [C] . M. Sullivan, B.C. Prorok Sensing for Agriculture and Food Quality and Safety . 2015

机译：一种基于磁共振松弛的生物传感器
5. Development of Electrospun Nanofiber Biosensor and Nuclear Magnetic Resonance Based Biosensor for Rapid Pathogen Detection [D] . Luo, Yilun. 2020

机译：电纺纳米纤维生物传感器和基于核磁共振的快速病原体检测的发展
6. Study on Paramagnetic Interactions of (CH3NH3)2CoBr4 Hybrid Perovskites Based on Nuclear Magnetic Resonance (NMR) Relaxation Time [O] . Ae Ran Lim, Sun Ha Kim 2019

机译：基于核磁共振（NMR）弛豫时间的（CH3NH3）2CoBr4杂化钙钛矿顺磁性相互作用的研究
7. Rapid Fire Abstract: Multimodality imaging valvular heart disease742Quantification of aortic regurgitation by pulsed Doppler examination of the left subclavian artery velocity contour: a validation study with cardiac magnetic resonance imaging743Diastolic retrograde flow in the descending aorta by cardiovascular magnetic resonance imaging for the quantification of aortic regurgitation744Native T1 relaxation time can accurately identify limited left ventricular contractile reserve in patients with aortic stenosis745The validation and assessment of myocardial fibrosis by using cardiac magnetic resonance and speckle-tracking echocardiography in severe aortic stenosis746Clinical validation of a semi-automatic quantification score of aortic valve calcification with ultrasound747A comparison among conventional 3D-transesophageal echocardiography manual analysis, 3D automatic software analysis and computed tomography for the aortic annulus sizing in TAVI patients748New insights from a multimodality imaging evaluation of LV remodeling in patients with chronic ischemic mitral regurgitation: a combined magnetic resonance and speckle tracking analysis749Multimodality imaging monitoring during percutaneous tricuspid valve repair procedures [O] . RA. Spampinato, A. Kammerlander, T. Ondrus, 2016

机译：快速火灾摘要：脉冲多普勒检测左锁骨期动脉轮廓脉冲多普勒检查的多模成像瓣膜病程742，用心血管磁共振成像与心血管磁共振成像中的心脏磁共振成像对心血管磁共振成像的验证研究。主动脉磁性共振成像7444放松时间可以在主动脉狭窄患者中准确识别有限的左心室收缩储备，通过使用心脏磁共振和散斑狭窄的斑点狭窄746临床验证，对主动脉瓣钙化与超声阀钙化的验证和散斑跟踪超声心动术进行验证和评估心肌纤维化的验证和评估。在常规的3D-经乳管超声心动图中，3D自动软件分析和计算断层扫描的主动脉环抑制在Tavi患者中的尺寸748新的洞察力组合的磁共振和斑点追踪analysis749Multimodality成像期间经皮三尖瓣修复过程监测：在患者重塑慢性缺血性二尖瓣反流的LV dality成像评价
8. The Effects of Paramagnetic Relaxation Reagents on 15N Spin Relaxation and the Use of Gd(dpm)3 as a Nitrogen-15 Nuclear Magnetic Resonance Spin Label [R] . Levy, G. C. , Dechter, J. J. , Kowalewski, J. 1977

机译：顺磁弛豫试剂对15N自旋弛豫的影响及Gd（dpm）3作为氮-15核磁共振自旋标记的应用

A biosensor based on magnetic resonance relaxation

摘要

著录项

相似文献

相关主题

期刊订阅