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Quantum Dots in Life Sciences: Applications, Benefits and Safety Issues

机译:生命科学中的量子点:应用,益处和安全性问题

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Luminescent semiconductor quantum dots (QDs) possess several unique optical and spectroscopic properties including high quantum yields, broad absorption spectra coupled to narrow symmetric, size-tunable emissions allowing large achievable Stokes shifts, and exceptional resistance to photo- and chemical degradation. These properties make QDs unique enabling materials for the development of the next generation of highly efficient biosensors for health security applications, particularly within the context of living and fixed cells. Paramount in this developmental process is addressing the biocompatibility of the QD materials. We are developing robust and facile delivery schemes for the selective intracellular delivery of QD-based nanoassemblies. These schemes are based upon the self-assembly and subsequent cellular uptake of QD-peptide and QD-polymer bioconjugates. Cellular delivery experiments utilizing both delivery schemes will be presented. The advantages and disadvantages of each approach will be discussed, including the intracellular fate and stability of the QD-nanoassemblies.
机译:发光半导体量子点(QD)具有几个独特的光学和光谱特性,包括高量子产率,宽吸收光谱与窄对称,尺寸可调的发射耦合,允许较大的斯托克斯位移,以及出色的抗光化学降解性能。这些特性使QD成为独特的使能材料,尤其是在活细胞和固定细胞的情况下,这些材料可用于开发下一代高效健康传感器,用于健康安全应用。在这一发展过程中,最重要的是解决量子点材料的生物相容性。我们正在为基于QD的纳米组件的选择性细胞内传递开发强大而便捷的传递方案。这些方案基于QD肽和QD聚合物生物共轭物的自组装和随后的细胞摄取。将介绍利用两种递送方案的细胞递送实验。将讨论每种方法的优缺点,包括QD纳米组件的细胞内命运和稳定性。

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