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首页> 外文会议>Single molecule spectroscopy and superresolution imaging VII >Fluorescent Nanodiamonds for Ultrasensitive Detection
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Fluorescent Nanodiamonds for Ultrasensitive Detection

机译：荧光纳米金刚石用于超灵敏检测

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摘要

Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.
机译：荧光纳米金刚石（NDs）是新兴的纳米材料，有潜力用作荧光成像剂，还可以用作功能广泛的平台，以控制各种治疗剂的功能化和递送。我们将利用两种实验方法：TIRF，这是一种基于全内反射荧光和SPRF的相对简单的方法，该荧光通过与表面等离子体激元共振耦合而增强。我们估计，基于检测器，SPRF方法的灵敏度将是目前可用的类似检测器的100倍。这项研究的最终目标是开发可用于灵敏，快速和廉价的基因测序和蛋白质检测的微阵列平台。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Joseph Kimball; Dymtro Shumilov; Badri Maliwa; T.W. Zerda; Bibhu Rout; Rafal Fudala; Sangram Raut; Ignacy Gryczynski; Eric Simanek; Julian Borejdo; Ryan Rich; Irina Akopova; Zygmunt Gryczynski;

  • 作者单位

    Department of Physics and Astronomy, Texas Christian University;

    Department of Physics and Astronomy, Texas Christian University;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Department of Physics and Astronomy, Texas Christian University;

    Department of Physics, University of North Texas;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Department of Physics and Astronomy, Texas Christian University;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Department of Chemistry, Texas Christian University;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

    Department of Physics and Astronomy, Texas Christian University,Center for Commercialization of Fluorescence Technologies, Department of Molecular Biology and Immunology, University of North Texas Health Science Center;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    nanodiamonds; TIRF; SPRF;

    机译：纳米金刚石TIRF; SPRF;

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