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High-sensitivity hyper-spectral imager for biomedical video diagnostic applications

机译：用于生物医学视频诊断应用的高灵敏度高光谱成像仪

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Video endoscopy allows physicians to visually inspect inner regions of the human body using a camera and only minimal invasive optical instruments. It has become an every-day routine in clinics all over the world. Recently a technological shift was done to increase the resolution from PAL/NTSC to HDTV. But, despite a vast literature on in-vivo and in-vitro experiments with multi-spectral point and imaging instruments that suggest that a wealth of information for diagnostic overlays is available in the visible spectrum, the technological evolution from colour to hyper-spectral video endoscopy is overdue. There were two approaches (NBI, OBI) that tried to increase the contrast for a better visualisation by using more than three wavelengths. But controversial discussions about the real benefit of a contrast enhancement alone, motivated a more comprehensive approach using the entire spectrum and pattern recognition algorithms. Up to now the hyper-spectral equipment was too slow to acquire a multi-spectral image stack at reasonable video rates rendering video endoscopy applications impossible. Recently, the availability of fast and versatile tunable filters with switching times below 50 microseconds made an instrumentation for hyper-spectral video endoscopes feasible. This paper describes a demonstrator for hyper-spectral video endoscopy and the results of clinical measurements using this demonstrator for measurements after otolaryngoscopic investigations and thorax surgeries. The application investigated here is the detection of dysplastic tissue, although hyper-spectral video endoscopy is of course not limited to cancer detection. Other applications are the detection of dysplastic tissue or polyps in the colon or the gastrointestinal tract.
机译：视频内窥镜允许医生使用照相机和仅微创光学仪器在视觉上检查人体的内部区域。它已成为世界各地诊所的日常工作。最近，为了将分辨率从PAL / NTSC提高到HDTV，进行了技术转移。但是，尽管有大量关于使用多光谱点和成像仪器进行的体内和体外实验的文献表明，在可见光谱中可以获取大量用于诊断叠加的信息，但从彩色到高光谱视频的技术发展内镜检查已过期。有两种方法（NBI，OBI）试图通过使用三个以上的波长来增加对比度以实现更好的可视化。但是，关于仅增强对比度的真正好处的争议性讨论激发了使用整个光谱和模式识别算法的更全面方法。到目前为止，高光谱设备太慢，无法以合理的视频速率获取多光谱图像堆栈，因此无法进行视频内窥镜检查应用。近来，切换时间低于50微秒的快速，通用的可调滤波器的可用性使高光谱视频内窥镜的仪器变得可行。本文介绍了一种用于高光谱视频内窥镜的演示器，以及使用该演示器进行耳镜检查和胸部手术后的测量的临床测量结果。尽管高光谱视频内窥镜当然不限于癌症检测，但此处研究的应用是增生组织的检测。其他应用是检测结肠或胃肠道中增生异常的组织或息肉。

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