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Quantitative Analysis of Low Contrast Detectability in Optical Coherence Tomography

机译:光学相干断层扫描中低对比度可检测性的定量分析

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摘要

Optical coherence tomography (OCT) is a high resolution imaging technology that is rapidly being adopted as the standard of care for medical applications such as ocular and intravascular imaging. However, clinical translation has been hampered by the lack of standardized test methods for performance evaluation as well as consensus standards analogous to those that have been developed for established medical imaging modalities (e.g., ultrasound). In this study, we address low contrast detectability, specifically, the ability of systems to differentiate between regions exhibiting small differences in scattering coefficient. Based on standard test methods for established medical imaging modalities, we have developed layered phantoms with well-characterized scattering properties in a biologically relevant range. The phantoms consisted of polydimethylsiloxane (PDMS) doped with varying concentrations of BaSO_4 microparticles. Microfabrication processes were used to create layered and channel schemes. Two spectral domain OCT systems - a Fourier domain system at 855 nm and a swept-source device at 1310 nm - were then used to image the phantoms. The detectability of regions with different scattering levels was evaluated for each system by measuring pixel intensity differences. Confounding factors such as the inherent attenuation of the phantoms, signal intensity decay due to focusing and system roll-off were also encountered and addressed. Significant differences between systems were noted. The minimum differences in scattering coefficient that the Fourier domain and swept source systems could differentiate was 1.50 and 0.46 mm~(-1) respectively. Overall, this approach to evaluating low contrast detectability represents a key step towards the development of standard test methods to facilitate clinical translation of novel OCT systems.
机译:光学相干断层扫描(OCT)是一种高分辨率成像技术,已迅速被用作眼部和血管内成像等医疗应用的护理标准。然而,由于缺乏用于性能评估的标准化测试方法以及与针对已建立的医学成像模式(例如,超声)而开发的共识标准相类似的共识标准,阻碍了临床翻译。在这项研究中,我们解决了低对比度的可检测性,特别是系统区分散射系数小的差异的区域的能力。基于已建立医学成像模式的标准测试方法,我们开发了具有良好生物学特性范围内散射特性的分层体模。体模由掺杂有不同浓度的BaSO_4微粒的聚二甲基硅氧烷(PDMS)组成。使用微细加工工艺来创建分层和通道方案。然后使用两个光谱域OCT系统-855 nm的傅立叶域系统和1310 nm的扫频源设备-对体模成像。对于每个系统,通过测量像素强度差异来评估具有不同散射级别的区域的可检测性。还遇到并解决了诸如幻影的固有衰减,由于聚焦和系统滚降引起的信号强度衰减等混杂因素。注意到系统之间的显着差异。傅里叶域和扫频源系统可分辨的最小散射系数差分别为1.50和0.46 mm〜(-1)。总体而言,这种评估低对比度可检测性的方法代表了标准测试方法发展的关键步骤,以促进新型OCT系统的临床翻译。

著录项

  • 来源
  • 会议地点 Baltimore MD(US)
  • 作者单位

    Fischell Dept. of Bioengineering, University of Maryland, College Park, MD 20742, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993;

    Fischell Dept. of Bioengineering, University of Maryland, College Park, MD 20742, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993;

    Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993;

    Fischell Dept. of Bioengineering, University of Maryland, College Park, MD 20742, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993;

    Fischell Dept. of Bioengineering, University of Maryland, College Park, MD 20742;

    Fischell Dept. of Bioengineering, University of Maryland, College Park, MD 20742;

    Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    phantom; optical coherence tomography; contrast; detectability;

    机译:幻影;光学相干断层扫描;对比;可检测性;

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